Conjugation of quinones with natural polyamines: towards an expanded anti-trypanosomatid profile (Publications)
A combinatorial library of quinone-polyamine conjugates designed to optimize the anti-trypanosomatid profile of hit compounds 1 and 2 has been prepared by a solid phase approach. The conjugates were e
Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides (Publications)
Tropical diseases are serious infectious diseases caused by protozoan parasites in tropical and subtropical regions Novel effective safe and inexpensive drugs are required to treat the parasites and c
Intermittent preventive treatment for malaria and anaemia control in Tanzanian infants; the development and implementation of a public health strategy (Publications)
Minimizing the time between efficacy studies and public health action is important to maximize health gains. We report the rationale, development and implementation of a district-based strategy for th
Genotypic and phenotypic characterization of <em>Trypanosoma brucei gambiense</em> isolates from Ibba, South Sudan, an area of high melarsoprol... (Publications)
Resistance of trypanosomes to melarsoprol is ascribed to reduced uptake of the drug via the P2 nucleoside transporter. The aim of this study was to look for evidence of drug resistance in Trypanosoma