Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection (Publications)
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoi
Targeting a large active site: structure-based design of nanomolar inhibitors of <em>Trypanosoma brucei </em>trypanothione reductase (Publications)
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas' disease, and leishmaniases. Introd
The HOSENG trial - effect of the provision of oral self-testing for absent and refusing individuals during a door-to-door HIV-testing campaign on... (Publications)
BACKGROUND: HIV-testing coverage remains below the targeted 90% despite efforts and resources invested. Home-based HIV-testing is a key approach endorsed by the World Health Organization (WHO), especi
Ambient particulate air pollution and daily mortality in 652 cities (Publications)
BACKGROUND: The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. METHODS: We evaluated the associa
VIBRA trial - effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among... (Publications)
BACKGROUND: There is a need for evaluating community-based antiretroviral therapy (ART) delivery models to improve overall performance of HIV programs, specifically in populations that may have diffic
Neglected tropical diseases in the People's Republic of China: progress towards elimination (Publications)
Since the founding of the People's Republic of China in 1949, considerable progress has been made in the control and elimination of the country's initial set of 11 neglected tropical diseases. Indeed,
Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (<em>Macaca fuscata yakui</em>) in Yakushima Island (Publications)
ETHNOPHARMACOLOGICAL RELEVANCE: Primates forage on a variety of plant parts to balance their dietary intake to meet requirements of energy, nutrition and maintenance, however the reason(s) leading the