Air pollution exposure assessment in sparsely monitored settings; applying machine-learning methods with remote sensing data in South Africa (Publications)
Air pollution is one of the leading environmental risk factors to human health – Both short and long-term exposure to air pollution impact human health accounting for over 4 million deaths. Although t
Thermal proteome profiling reveals <em>Haemonchus </em>orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868 (Publications)
Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy,
The communication chain of genetic risk: analyses of narrative data exploring proband-provider and proband-family communication in hereditary breast... (Publications)
Low uptake of genetic services among members of families with hereditary breast and ovarian cancer (HBOC) suggests limitations of proband-mediated communication of genetic risk. This study explored ho
A tiered approach for assessing individual and combined risk of pyrethroids using human biomonitoring data (Publications)
Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A
Egg-laying and locomotory screens with <em>C. elegans </em>yield a nematode-selective small molecule stimulator of neurotransmitter release (Publications)
Nematode parasites of humans, livestock and crops dramatically impact human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and tr
Does global health governance walk the talk? Gender representation in World Health Assemblies, 1948-2021 (Publications)
BACKGROUND: While an estimated 70%-75% of the health workforce are women, this is not reflected in the leadership roles of most health organisations-including global decision-making bodies such as the
Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT) (Publications)
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a men
Deconstructing design thinking as a tool for the implementation of a population health initiative (Publications)
BACKGROUND: The translation of evidence-based practices and rapid uptake of innovations into global health practice is challenging. Design thinking is a consultative process involving multiple stakeho
Different classes of genomic inserts contribute to human antibody diversity (Publications)
Recombination of antibody genes in B cells can involve distant genomic loci and contribute a foreign antigen-binding element to form hybrid antibodies with broad reactivity for Plasmodium falciparum.
