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1. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) (Publications)

   The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer)

   Relevance:

   Praziquantel has been the mainstay of schistosomiasis control since 1984 and widely distributed since 2006 through 'preventive chemotherapy' programmes to school-aged children or at-risk populations.

2. Activity of diimidazoline amides against <em>African trypanosomiasis</em> (Publications)

   Activity of diimidazoline amides against <em>African trypanosomiasis</em>

   Relevance:

   We identified several diimidazoline mono- and diamides that were as potent as pentamidine against Trypanosoma brucei rhodesiense in vitro. All of these were also less cytotoxic than pentamidine, but n

3. Female predominance and transmission distortion in the long-QT syndrome (Publications)

   Female predominance and transmission distortion in the long-QT syndrome

   Relevance:

   BACKGROUND: Congenital long-QT syndrome is a disorder resulting in ventricular arrhythmias and sudden death. The most common forms of the long-QT syndrome, types 1 and 2, are caused by mutations in th

4. Anti-tick vaccines for the control of ticks affecting livestock (Publications)

   Anti-tick vaccines for the control of ticks affecting livestock

   Relevance:

5. Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis (Publications)

   Epistasis between antibiotic resistance mutations drives the evolution of extensively drug-resistant tuberculosis

   Relevance:

6. Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase... (Publications)

   Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of <em>Plasmodium falciparum</em> enoyl-ACP-reductase (<em>Pf</em>FabI)

   Relevance:

   Malaria, a disease of worldwide significance, is responsible for over one million deaths annually. The liver-stage of Plasmodium's life cycle is the first, obligatory, but clinically silent step in ma

7. Substituted 2-phenyl-imidazopyridines: a new class of drug leads for human African trypanosomiasis (Publications)

   Substituted 2-phenyl-imidazopyridines: a new class of drug leads for human African trypanosomiasis

   Relevance:

   A phenotypic screen of a compound library for antiparasitic activity on Trypanosoma brucei, the causative agent of human African trypanosomiasis, led to the identification of substituted 2-(3-aminophe

8. Transcriptomic and lipidomic profiles of glycerolipids during <em>Arabidopsis</em> flower development (Publications)

   Transcriptomic and lipidomic profiles of glycerolipids during <em>Arabidopsis</em> flower development

   Relevance:

   Flower glycerolipids are the yet-to-be discovered frontier of the lipidome. Although ample evidence suggests important roles for glycerolipids in flower development, stage-specific lipid profiling in

9. A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalised modules for membrane antigens (GMMA) (Publications)

   A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on generalised modules for membrane antigens (GMMA)

   Relevance:

   INTRODUCTION: Neisseria meningitidis causes epidemics of meningitis in sub-Saharan Africa. These have mainly been caused by capsular group A strains, but W and X strains are increasingly contributing

10. Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1 (Publications)

    Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: part 1

    Relevance:

    A novel class of imidazopyridazines identified from whole cell screening of a SoftFocus kinase library was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resistant strain)