Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker (Publications)
BACKGROUND: Human African Trypanosomiasis (HAT, sleeping sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone
Integrating standardized whole genome sequence analysis with a global <em>Mycobacterium tuberculosis</em> antibiotic resistance knowledgebase (Publications)
Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is a collaborative, curated knowledgebase, designed to standardize and aggregate global Mycobacterium tubercul
<em>In vitro</em> and<em> in vivo</em> drug-drug interaction study of the effects of ivermectin and oxantel pamoate on tribendimidine (Publications)
Soil-transmitted helminth (STH) infections still remain a major health problem in poor rural settings. The lack of efficacious drugs against all STH species raises the interest in drug combinations. D
Environmental and health data needed to develop national surveillance systems in industrially contaminated sites (Publications)
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Public health surveillance (PHS) of industrially contaminated sites (ICSs) is likely to play a role in supporting the monitoring of
A review of exposure assessment methods for epidemiological studies of health effects related to industrially contaminated sites (Publications)
BACKGROUND: this paper is based upon work from COST Action ICSHNet. Health risks related to living close to industrially contaminated sites (ICSs) are a public concern. Toxicology-based risk assessmen
Challenges and lessons from conducting a paediatric clinical trial in sub-Saharan Africa: the case of the praziquantel oral dispersible tablets phase... (Publications)
The importance of implementing paediatric clinical trials for neglected tropical diseases (NTDs) in compliance with the Good Clinical Practices of the International Conference of Harmonisation (ICH-GC
Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective
Towards improved health service quality in Tanzania: An approach to increase efficiency and effectiveness of routine supportive supervision (Publications)
Effective supportive supervision of healthcare services is crucial for improving and maintaining quality of care. However, this process can be challenging in an environment with chronic shortage of qu
Bayesian geostatistical modelling of PM10 and PM2.5 surface level concentrations in Europe using high-resolution satellite-derived products (Publications)
Air quality monitoring across Europe is mainly based on in situ ground stations, which are too sparse to accurately assess the exposure effects of air pollution for the entire continent. The demand fo
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (Publications)
Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architect
