Spirometer replacement and serial lung function measurements in population studies: results from the SAPALDIA study (Publications)
The Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA), a population cohort study, used heated-wire spirometers in 1991 and 2002 and then ultrasonic spirometers in 201
Follow-up on genome-wide main effects: do polymorphisms modify the air pollution effect on lung function decline in adults? (Publications)
Improved air quality has been found associated with attenuated age-related decline in lung function. But whether genetic polymorphisms strongly associated with lung function play a modifying role in t
Forschung für Generationen (Publications)
Die ehemalige "Luft- und Lungen-Studie" SAPALDIA ist 20 Jahre alt geworden. Forscherinnen und Forscher aus verschiedensten Disziplinen untersuchen seit Jahren das Zusammenspiel von Umwelt und Gesundhe
Identification of a new locus at 16q12 associated with time-to-asthma onset (Publications)
BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS:
Genome-wide association study of lung function decline in adults with and without asthma (Publications)
BACKGROUND: Genome-wide association studies have identified determinants of chronic obstructive pulmonary disease, asthma, and lung function level; however, none have addressed decline in lung functio
Longitudinal validity of spirometers: a challenge in longitudinal studies (Publications)
QUESTION UNDER STUDY: Pulmonary function testing (PFT) in longitudinal studies involves the repeated use of spirometers over long time periods. We assess the comparability of PFT results taken under b
Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis (Publications)
The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pol