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1. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function (Publications)

   Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

   Relevance:

   BACKGROUND: Genome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung functi

2. Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey (Publications)

   Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey

   Relevance:

   BACKGROUND: Increased bronchial responsiveness is characteristic of asthma. Gas cooking, which is a major indoor source of the highly oxidant nitrogen dioxide, has been associated with respiratory sym

3. Health risk assessment along wastewater recovery and reuse systems in Kampala, Uganda and Hanoi, Vietnam (Publications)

   Health risk assessment along wastewater recovery and reuse systems in Kampala, Uganda and Hanoi, Vietnam

   Relevance:

4. The exposome in practice: design of the EXPOsOMICS project (Publications)

   The exposome in practice: design of the EXPOsOMICS project

   Relevance:

5. Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels (Publications)

   Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels

   Relevance:

   Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood. Since low AAT serum levels fail to protect pulmo

6. Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)

   Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis

   Relevance:

   Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors,

7. Common variants in Mendelian kidney disease genes and their association with renal function (Publications)

   Common variants in Mendelian kidney disease genes and their association with renal function

   Relevance:

   Many common genetic variants identified by genome-wide association studies for complex traits map to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common sing

8. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)

   Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

   Relevance:

   Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA

9. Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland (Publications)

   Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland

   Relevance:

   Given the shrinking spatial contrasts in outdoor air pollution in Switzerland and the trends toward tightly insulated buildings, the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in

10. Early detection of subjects at risk for vascular remodelling - results from the Swiss population-based study SAPALDIA (Publications)

    Early detection of subjects at risk for vascular remodelling - results from the Swiss population-based study SAPALDIA

    Relevance:

    QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal associati