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1. Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania (Publications)

   Prevalence of drug-resistance mutations and HIV-1 subtypes in a HIV-1 infected COHORT in rural Tanzania

   Relevance:

   ABSTRACT The development of resistance mutations in drug-targeted HIV-1 genes compromises the success of antiretroviral therapy (ART) programmes. Genotyping of these mutations enables adjusted therape

2. Health of mobile pastoralists in the Sahel - assessment of 15 years of research and development (Publications)

   Health of mobile pastoralists in the Sahel - assessment of 15 years of research and development

   Relevance:

   In the Sahel, between Mauritania and Somalia including Northern Kenya, about 20-30 million people live as mobile pastoralists. The rhythm of their migration follows the seasons and the availability of

3. Structure-activity relationship studies of pyrrolone antimalarial agents (Publications)

   Structure-activity relationship studies of pyrrolone antimalarial agents

   Relevance:

   Previously reported pyrrolones, such as TDR32570, exhibited potential as antimalarial agents; however, while these compounds have potent antimalarial activity, they suffer from poor aqueous solubility

4. Treatment of mucosal leishmaniasis (<em>L. infantum</em>) with Miltefosine in a patient with good syndrome (Publications)

   Treatment of mucosal leishmaniasis (<em>L. infantum</em>) with Miltefosine in a patient with good syndrome

   Relevance:

   We report on a 76-year old patient with recurrent mucosal leishmaniasis. Multiple treatment regimens were administered. After the second relapse, immunologic workup and review of the patient's history

5. Development and back-extrapolation of NO2 land use regression models for historic exposure assessment in Great Britain (Publications)

   Development and back-extrapolation of NO2 land use regression models for historic exposure assessment in Great Britain

   Relevance:

   Modelling historic air pollution exposures is often restricted by availability of monitored concentration data. We evaluated back-extrapolation of LUR models for annual mean NO2 concentrations in Grea

6. Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga province, Democratic Republic of... (Publications)

   Sociocultural determinants of anticipated vaccine acceptance for acute watery diarrhea in early childhood in Katanga province, Democratic Republic of Congo

   Relevance:

   Rotavirus and oral cholera vaccines have the potential to reduce diarrhea-related child mortality in low-income settings and are recommended by the World Health Organization. Uptake of vaccination dep

7. Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep (Publications)

   Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with <em>Fasciola hepatica</em> in sheep

   Relevance:

   Fasciolosis is a parasitosis caused by the food-borne trematode Fasciola spp. of major veterinary significance. Triclabendazole is the first line treatment in humans and animals but cases of resistanc

8. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)

   Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the <em>Plasmodium falciparum</em> dUTPase

   Relevance:

   Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationall

9. Comparison of performance of land use regression models derived for Catalunya, Spain (Publications)

   Comparison of performance of land use regression models derived for Catalunya, Spain

   Relevance:

10. Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix... (Publications)

    Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix jacchus</em>)

    Relevance:

    Existing small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. To dev