Efficacy, safety, and dose of pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b... (Publications)
BACKGROUND: Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Changes in malaria burden and transmission in sentinel sites after the roll-out of long-lasting insecticidal nets in Papua New Guinea (Publications)
BACKGROUND: Papua New Guinea exhibits a complex malaria epidemiology due to diversity in malaria parasites, mosquito vectors, human hosts, and their natural environment. Heterogeneities in transmissio
Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the Heinz Nixdorf... (Publications)
BACKGROUND: Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been propose
Spatial distribution of <em>Mycobacterium ulcerans</em> in Buruli ulcer lesions: implications for laboratory diagnosis (Publications)
BACKGROUND: Current laboratory diagnosis of Buruli ulcer (BU) is based on microscopic detection of acid fast bacilli, quantitative real-time PCR (qPCR), histopathology or cultivation. Insertion sequen
Wayanin and guaijaverin, two active metabolites found in a <em>Psidium acutangulum</em> Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae)... (Publications)
ETHNOPHARMACOLOGICAL RELEVANCE: Psidium acutangulum Mart. ex DC is a small tree used by the Wayana Amerindians from the Upper-Maroni in French Guiana for the treatment of malaria. AIM OF THE STUDY: In
Comparative study of activities of a diverse set of anti-mycobacterial agents against <em>Mycobacterium tuberculosis</em> and <em>Mycobacterium... (Publications)
A library of compounds covering a broad chemical space was selected from a tuberculosis drug development program and screened in a whole cell assay against Mycobacterium ulcerans, the causative agent
Toxocariasis-associated cardiac diseases: a systematic review of the literature (Publications)
Toxocariasis, caused by Toxocara canis or Toxocara catis, is a worldwide occurring parasitic disease, reaching high prevalences especially in tropical and subtropical countries. The clinical presentat
Validation of a point-of-care circulating cathodic antigen urine cassette test for <em>Schistosoma mansoni</em> diagnosis in the Sahel, and potential... (Publications)
On the shores of Lake Chad, schistosomiasis among mobile pastoralists was investigated in a field laboratory. Point-of-care circulating cathodic antigen (POC-CCA) cassette test, reagent strips, and fi