Immunopeptides in the defense reactions of <em>Glossina morsitans</em> to bacterial and <em>Trypanosoma brucei</em> <em>brucei</em> infections (Publications)
Several dipteran insects are vectors of parasites causing major human infectious diseases. Among these, the tsetse fly, Glossina spp., is responsible for the transmission of trypanosomes, the pathogen
Characterization of a defensin from the sand fly <em>Phlebotomus duboscqi</em> induced by challenge with bacteria or the protozoan parasite... (Publications)
Antimicrobial peptides are major components of the innate immune response of epithelial cells. In insect vectors, these peptides may play a role in the control of gut pathogens. We have analyzed antim
Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect<em> Stomoxys calcitrans</em> (Publications)
The gut epithelium is an essential interface in insects that transmit parasites. We investigated the role that local innate immunity might have on vector competence, taking Stomoxys calcitrans as a mo
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from <em>Ancistrocladus tanzaniensis</em> (Publications)
Three new naphthylisoquinoline alkaloids, the 7,3'-coupled ancistrotanzanine C (6), the 5,1'-coupled O-methylancistrocladinine (7), and the likewise 5,1'-coupled O,N-dimethylancistrocladine (8, previo
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids (Publications)
The naphthylisoquinoline alkaloids (NIQs) represent a class of natural products with manifold activities against various tropical diseases. They are isolated from rare and difficult-to-cultivate tropi
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines (Publications)
The naphthylisoquinoline (NIQ) alkaloids from tropical Ancistrocladaceae and Dioncophyllaceae plants show high antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strain