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1. Implementation of a non-communicable disease clinic in rural Sierra Leone: early experiences and lessons learned (Publications)

   Implementation of a non-communicable disease clinic in rural Sierra Leone: early experiences and lessons learned

   Relevance:

   This study is an evaluation of the first cohort of patients enrolled in an outpatient non-communicable disease clinic in Kono, Sierra Leone. In the first year, the clinic enrolled 916 patients. Eight

2. Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not... (Publications)

   Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

   Relevance:

   The Mycobacterium ulcerans exotoxin, mycolactone, is responsible for the immunosuppression and tissue necrosis that characterizes Buruli ulcer. Mycolactone inhibits SEC61-dependent co-translational tr

3. Moderate-to-vigorous physical activity is associated with cardiorespiratory fitness among primary schoolchildren living in Côte d'Ivoire, South... (Publications)

   Moderate-to-vigorous physical activity is associated with cardiorespiratory fitness among primary schoolchildren living in Côte d'Ivoire, South Africa, and Tanzania

   Relevance:

   Background: Physical inactivity and low cardiorespiratory fitness (CRF) are independent cardiovascular risk factors among children, but have rarely been investigated concurrently in sub-Saharan Africa

4. Low sensitivity of real time PCRs targeting retrotransposon sequences for the detection of <em>Schistosoma japonicum </em>complex DNA in human serum (Publications)

   Low sensitivity of real time PCRs targeting retrotransposon sequences for the detection of <em>Schistosoma japonicum </em>complex DNA in human serum

   Relevance:

   While hybridization probe-based real-time PCR assays targeting highly repetitive multi-copy genome sequences for the diagnosis of S. mansoni complex or S. haematobium complex from human serum are well

5. Long-term neurological and psychological distress symptoms among smallholder farmers in Costa Rica with a history of acute pesticide poisoning (Publications)

   Long-term neurological and psychological distress symptoms among smallholder farmers in Costa Rica with a history of acute pesticide poisoning

   Relevance:

   Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having ex

6. Perception of cure among leprosy patients post completion of multi-drug therapy (Publications)

   Perception of cure among leprosy patients post completion of multi-drug therapy

   Relevance:

   BACKGROUND: Leprosy is a treatable disease; however, the release from treatment after completion of multidrug therapy (MDT) often does not equal absence of health problems. Consequently, sequelae inte

7. TIDE analysis of <em>Cryptosporidium </em>infections by <em>gp60 </em>typing reveals obscured mixed infections (Publications)

   TIDE analysis of <em>Cryptosporidium </em>infections by <em>gp60 </em>typing reveals obscured mixed infections

   Relevance:

   BACKGROUND: Cryptosporidiosis is a parasitic disease associated with potentially fatal diarrhea. The most used method in Cryptosporidium subtyping is based on the glycoprotein gene gp60. Each infectio

8. Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of <em>Klebsiella oxytoca</em> group in invasive infections: a retrospective... (Publications)

   Whole-genome sequence-informed MALDI-TOF MS diagnostics reveal importance of <em>Klebsiella oxytoca</em> group in invasive infections: a retrospective clinical study

   Relevance:

   BACKGROUND: Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiell

9. Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review (Publications)

   Same-day antiretroviral therapy initiation for people living with HIV who have tuberculosis symptoms: a systematic review

   Relevance:

   OBJECTIVES: Tuberculosis symptoms are very common among people living with HIV (PLHIV) initiating antiretroviral therapy (ART), are not specific for tuberculosis disease and may result in delayed ART

10. Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype (Publications)

    Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

    Relevance:

    This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural prod