Seasonally dependent relationships between Indicators of malaria transmission and disease provided by mathematical model simulations (Publications)
levels of malaria transmission, patterns of seasonality and access to treatment were run with an ensemble of models of malaria epidemiology and within-host dynamics, as part of the OpenMalaria modeling [...] relationships between malaria indicators allowing more easily measured data, such as routine health systems data on case incidence, to be translated into measures of transmission and other malaria indicators. [...] previously published data on these same indicators as observed in malaria...
Made-to-measure malaria vector control strategies: rational design based on insecticide properties and coverage of blood resources for mosquitoes (Publications)
Eliminating malaria from highly endemic settings will require unprecedented levels of vector control. To suppress mosquito populations, vector control products targeting their blood hosts must attain high
A household randomized, controlled trial of the efficacy of 0.03% transfluthrin coils alone and in combination with long-lasting insecticidal nets on... (Publications)
evidence that burning mosquito coils prevents malaria acquisition. Therefore, the current trial was designed to measure and compare prevention of malaria infection by mosquito coils or long-lasting in [...] members that regularly slept away from home. The main outcome of interest was Plasmodium falciparum malaria prevalence detected by rapid diagnostic tests (RDTs) during six repeated monthly cross-sectional [...] This is the first robust clinical evaluation of transfluthrin mosquito coils as a...
Community-owned resource persons for malaria vector control: enabling factors and challenges in an operational programme in Dar es Salaam, United... (Publications)
remains complex and poorly understood. The Urban Malaria Control Program (UMCP) in Dar es Salaam, United Republic of Tanzania, implements larval control of malaria vector mosquitoes. The UMCP delegates resp
Micro-encapsulated pirimiphos-methyl shows high insecticidal efficacy and long residual activity against pyrethroid-resistant malaria vectors in... (Publications)
e-treated nets and indoor residual spraying (IRS) has contributed to a considerable decrease of malaria morbidity and mortality in sub-Saharan Africa over the last decade. Due to increasing resistance [...] for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries. METHODS: Three experimental capsule suspension (CS) formulations of the organ [...] alternatives for IRS, as they demonstrate prolonged insecticidal effect and residual...
Increasing role of <em>Anopheles funestus</em> and <em>Anopheles arabiensis</em> in malaria transmission in the Kilombero Valley, Tanzania (Publications)
order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This [...] This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contribution to malaria transmission in hyperendemic transmission settings in Tanzania. METHODS: The study was [...] arabiensis susceptibility to insecticides was assessed using WHO guidelines....
Efficacy and safety of dihydroartemisinin-piperaquine for treatment of <em>Plasmodium vivax</em> malaria in endemic countries: meta-analysis of... (Publications)
the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. METHODOLOGY AND PRINCIPAL FINDINGS: This is a meta-analysis [...] Findings document that DHP is more efficacious than CQ and AL in treating uncomplicated P. vivax malaria. The better safety profile of DHP and the once-daily dosage improves adherence, and its fixed co [...] the potential to become an alternative antimalarial drug for the treatment...
Orally active antischistosomal early leads identified from the open access malaria box (Publications)
drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro [...] respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry
Malaria case management in Papua New Guinea following the introduction of a revised treatment protocol (Publications)
fever or suspected malaria patients and via an interviewer administered questionnaire completed with the officer in charge of each participating health care facility. RESULTS: Malaria rapid diagnostic tests [...] 445) were tested for malaria by RDT and 39% prescribed an anti-malarial, inclusive of 98.2% of RDT positive patients and 19.8% of RDT negative cases. The availability and use of malaria RDTs was greater in [...] CONCLUSIONS: PNG has achieved high coverage of malaria RDTs and AL at the...
Naturally acquired immune responses to <em>P. vivax</em> merozoite surface protein 3alpha and merozoite surface protein 9 are associated with reduced... (Publications)
is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas [...] and Merozoite Surface Protein 9 (PvMSP9) were measured and related to prospective risk of P. vivax malaria during 16 months of active follow-up. Overall, there was a low prevalence of antibodies to PvMSP3alpha [...] PvMSP9 N-terminus (aIRR = 0.68, p = 0.035) were associated with protection...