Child Health and Infection with Low Density (CHILD) Malaria, a randomized controlled trial to assess the long-term health and socioeconomic impact of... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/child-health-and-infection-with-low-density-child-malaria-a-randomized-controlled-trial-to-assess-the-long-term-health-and-socioeconomic-impact-of-interventions-targeting-low-density-malaria-infection-lmi-among-children-in-tanzania
As malaria transmission declines, an increasing proportion of infections persist in the body at low levels. Low-density malaria infection (LMI) are often chronic and represent a high proportion of infections [...] they may provide protective immunity again future malaria illness. There is a growing body evidence to suggest that LMI are associated with recurrent malaria, chronic anemia, poor growth, co-infection with [...] for malaria (using RDT and qPCR) three times annually, with AL...
Scoping Study for a Strategic Environmental Assessment (SEASS) on the potential operational use of gene drive in the main malaria-carrying Anopheles... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/scoping-study-for-a-strategic-environmental-assessment-seass-on-the-potential-operational-use-of-gene-drive-in-the-main-malaria-carrying-anopheles-mosquito-species-in-west-africa-on-behalf-of-target-malaria
Target Malaria isa not-for-profit research consortium that aims to develop and share new, cost-effective, and sustainable genetic technologies to modify mosquitoes and reduce malaria transmission. The [...] The intervention which is currently in development by Target Malaria (i.e. a population suppression gene drive) works by reducing the ability of female mosquitoes to reproduce through non-mendelian inheritance [...] inheritance of an introduced gene targeting female fertility, thereby...
OpenMalaria Workflow and OpenMalariaUtilities R Packages (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/openmalaria-workflow-and-openmalariautilities-r-packages
Swiss TPH GitHub . OpenMalariaUtilities R Package At the core of our OpenMalaria Workflow is the OpenMalariaUtilities R package which is developed to allow the use of OpenMalaria directly from R. The package [...] OpenMalaria Workflow R Package The work of the Analytics and Intervention Modelling Group is based on OpenMalaria : an open-source C++ program for simulating malaria epidemiology and the impacts on that [...] TPH GitHub. The OpenMalaria Workflow R Package together with the OpenMalariaU...
Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
Intravenous artesunate improves survival in severe malaria, but clinical trial data from non-endemic countries are scarce. The TropNet severe malaria database was analyzed to compare outcomes of artesunate [...] clearance time, duration of ICU- and hospital treatment in European patients with imported severe malaria
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
and distribution of malaria cases. This article describes molecular epidemiologic investigations currently being carried out by the International Centers of Excellence for Malaria Research (ICEMR) network [...] network in a variety of malaria-endemic settings. First, we discuss various novel approaches to understand malaria incidence and gametocytemia, focusing on Plasmodium falciparum and Plasmodium vivax. Second [...] methods commonly used in malaria epidemiology and population genetics....