Epidemiologie und Klinik der Malaria in der Schweiz (Publications)
thirds of all cases of malaria in Switzerland are imported from Africa. Accordingly, malignant malaria is more frequently diagnosed in Switzerland than tertian malaria. Malignant malaria usually presents atypically [...] shock. The lethality is high. The majority of Swiss travellers are not protected effectively against malaria. A group particularly at risk are tourists of 20--30 years of age. It is suggested that travel agencies [...] the medical profession should intensify public information...
Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria (Publications)
quinidine, usually stocked by hospitals, is an alternative drug for malaria treatment. We report the cases of two patients with severe malaria imported from Kenya. They were treated first with intravenous quinidine [...] Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug [...] mg/kg b.w./die of quinidine given intravenously seems to be an adequate...
The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression [...] maintenance. In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members
Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries (Publications)
BACKGROUND: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac [...] isinin)-piperaquine (APQ) Eurartesim((R)) during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. The present [...] 255/257 (99.2%). CONCLUSIONS: APQ appears as an effective and well-tolerated...
Incidence of <em>Plasmodium falciparum</em> malaria infection in 6-month to 45-year-olds on selected areas of Bioko Island, Equatorial Guinea (Publications)
were 58 malaria infection episodes observed during the follow up period, including 47 first and 11 repeat infections. The incidence of malaria was 0.25 [95% CI (0.19, 0.32)] and of first malaria was 0.23 [...] study area, gender, malaria positivity at screening, and household socioeconomic status independently predicted the observed incidence of malaria. CONCLUSION: Despite intensive malaria control efforts on [...] BACKGROUND: Extensive malaria control measures have been implemented on Bioko...
Prevalence and risk factors for malaria in pregnancy in Vanga, Democratic Republic of Congo (Publications)
(DRC) is the second most malarious country in the world, but little information is available on malaria control measures in pregnancy. We conducted a longitudinal study among 395 women pregnant with singletons [...] Vanga Health Zone, Kwilu Province. We recruited 406 pregnant women between April and October 2019. Malaria prevalence at recruitment was 18.8% in Vanga and 30.1% in Mayoko (difference p
Delayed cerebellar ataxia, a rare post-malaria neurological complication: case report and review of the literature (Publications)
Delayed cerebellar ataxia (DCA) is a rare post-malarial neurological complication with unknown pathomechanism characterized by its self-limiting course and favorable outcome. We report a case of DCA f
Estimating intervention effectiveness in trials of malaria interventions with contamination (Publications)
Background In cluster randomized trials (CRTs) or stepped wedge cluster randomized trials (SWCRTs) of malaria interventions, mosquito movement leads to contamination between trial arms unless buffer zones separate [...] s are provided as a function of intervention coverage. The methods are applied to two SWCRTs of malaria interventions, the SolarMal trial on the impact of mass trapping of mosquitoes with odor-baited traps [...] effectiveness as a function of coverage. Conclusions The...
Unlocking the human factor to increase effectiveness and sustainability of malaria vector control (Publications)
decade in the fight against malaria there is a critical opportunity to elevate the role of social and behaviour change to increase the impact and sustainability of malaria control and elimination efforts [...] BACKGROUND: Progress in the fight against malaria has stalled in recent years, highlighting the importance of new interventions and tailored approaches. A critical factor that must be considered across [...] research with entomological and epidemiological evaluations will provide a more...