MalHaploFreq: a computer programme for estimating malaria haplotype frequencies from blood samples (Publications)
are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood [...] present (i.e. its prevalence), but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish
Residual antimalarials in malaria patients from Tanzania - implications on drug efficacy assessment and spread of parasite resistance (Publications)
BACKGROUND: Repeated antimalarial treatment for febrile episodes and self-treatment are common in malaria-endemic areas. The intake of antimalarials prior to participating in an in vivo study may alter treatment [...] n of both efficacy and safety outcomes. We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual
Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam (Publications)
confirm malaria cases in Tanzania is low and presumptive treatment of malaria is being practiced widely. In malaria endemic areas WHO now recommends systematic laboratory testing when suspecting malaria. Currently [...] Currently, the use of Rapid Diagnostic Tests (RDTs) is recommended for the diagnosis of malaria in lower level peripheral facilities, but not in health centres and hospitals. In this study, the following [...] quality of routine microscopy, and (2) the effects of RDT...
Interdependence of domestic malaria prevention measures and mosquito-human interactions in urban Dar es Salaam, Tanzania (Publications)
BACKGROUND: Successful malaria vector control depends on understanding behavioural interactions between mosquitoes and humans, which are highly setting-specific and may have characteristic features in [...] mosquito biting patterns in Dar es Salaam, Tanzania are examined and the protection against exposure to malaria transmission that is afforded to residents by using an insecticide-treated net (ITN) is estimated
Bayesian geostatistical modeling of Malaria Indicator Survey data in Angola (Publications)
2006-2007 Angola Malaria Indicator Survey (AMIS) is the first nationally representative household survey in the country assessing coverage of the key malaria control interventions and measuring malaria-related [...] number of parasitaemic children produced in this paper are important for planning and implementing malaria control interventions and for monitoring the impact of prevention and control activities
Assessing the impact of next-generation rapid diagnostic tests on <em>Plasmodium falciparum</em> malaria elimination strategies (Publications)
n strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future
Social and cultural aspects of 'malaria' and its control in central Côte d'Ivoire (Publications)
behaviour is important for the effective control of malaria. The purpose of this study was to assess the knowledge, attitudes, practices and beliefs of 'malaria' and its control in two rural communities of central [...] employing a household asset-based approach. RESULTS: Malaria was identified as djekouadjo, the local folk name of the disease. Although people were aware of malaria-related symptoms and their association with [...] central Cote d'Ivoire, and to examine associations between 'mala...