Acridine Orange for malaria diagnosis: its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria... (Publications)
for the organization of health services and the provision of effective treatment of malaria cases. The national malaria control programme of Tanzania, together with the Japan International Co-operation Agency [...] One hundred years ago, Giemsa's stain was employed for the first time for malaria diagnosis. Giemsa staining continues to be the method of choice in most malarious countries, although, in the recent past [...] Acridine Orange (AO). The literature on the discovery, development and...
Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria... (Publications)
BACKGROUND: Malaria burden in Uganda has declined disproportionately among regions despite overall high intervention coverage across all regions. The Uganda Malaria Indicator Survey (MIS) 2014-15 was the [...] intervention effects on malaria prevalence in Uganda among children less than 5 years, assess intervention effects at regional level, and estimate geographical distribution of malaria prevalence in the country [...] on malaria prevalence at national and regional levels. Spike-and-slab...
False-negative malaria rapid diagnostic tests in Rwanda: impact of <em>Plasmodium falciparum</em> isolates lacking <em>hrp2</em> and declining malaria... (Publications)
and the Plasmodium lactate dehydrogenase (pLDH) to microscopy (thick smears) for the diagnosis of malaria. PCR was used to determine whether deletions of the histidine-rich central repeat region of the hrp2 [...] CONCLUSION: This prospective study of RDT performance coincided with a decline in the intensity of malaria transmission in Kibirizi (fall in slide positivity from 46 to 3%). This decline was associated with [...] could reduce the impact of false-negative HRP2-based RDTs for detection of...
Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent... (Publications)
Malaria continues to be one of mankind's most devastating diseases despite the many and varied efforts to combat it. Indispensable for malaria elimination and eventual eradication is the development of [...] of effective vaccines. Controlled human malaria infection (CHMI) is an invaluable tool for vaccine efficacy assessment and investigation of early immunological and molecular responses against Plasmodium [...] cell cycle, phosphatidylinositol signaling and erythrocyte development. Our study...