Child health and infection with low density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and... (Publications)
participants receive malaria testing using RDT and qPCR three times annually, and malaria testing by RDT only when presenting with fever. PCDm and PCD participants receive malaria testing by RDT and qPCR [...] INTRODUCTION: As malaria declines, low-density malaria infections (LMIs) represent an increasing proportion of infections and may have negative impacts on child health and cognition, necessitating development [...] respectively, when presenting with fever. RDT or qPCR positive...
Malaria treatment for prevention: a modelling study of the impact of routine case management on malaria prevalence and burden (Publications)
to explore how increasing treatment of symptomatic cases impacts malaria prevalence and incidence. METHODS: Leveraging the OpenMalaria stochastic agent-based transmission model, we first simulated an array [...] BACKGROUND: Testing and treating symptomatic malaria cases is crucial for case management, but it may also prevent future illness by reducing mean infection duration. Measuring the impact of effective [...] and 54% incorporated to reflect the 2023 coverage distribution across Africa, as...
Attitudes, practices, and determinants of community care-seeking behaviours for fever/malaria episodes in the context of the implementation of... (Publications)
FGDs showed that participants had good knowledge about malaria symptoms, prevention tools, and effective treatment. Behaviour change regarding malaria treatment and free medication for children under five [...] CONCLUSIONS: The study showed appropriate knowledge about malaria and positive community care-seeking behaviour at health centres for fever/malaria episodes. This could potentially facilitate the implementation [...] BACKGROUND: Malaria case management relies on World Health Organization...
Reflections on the 2021 World Malaria Report and the future of malaria control (Publications)
The World Malaria Report, released in December 2021, reflects the unique challenges currently facing the global malaria community. The report showed the devastating toll of malaria, with an estimated 627 [...] the capacity of the continent to address the malaria challenge. African countries also face a convergence of biological threats that could redefine malaria control, notably widespread pyrethroid resistance [...] presents key insights from the 2021 World Malaria Report and reflections on...
Vector composition, abundance, biting patterns and malaria transmission intensity in Madang, Papua New Guinea: assessment after 7 years of an... (Publications)
BACKGROUND: A malaria control programme based on distribution of long-lasting insecticidal bed nets (LLINs) and artemisinin combination therapy began in Papua New Guinea in 2009. After implementation of [...] of the programme, substantial reductions in vector abundance and malaria transmission intensity occurred. The research reported here investigated whether these reductions remained after seven years of [...] Anopheles per screen-night and 2.2-31.1 Anopheles per person-night), and spatially...
Early whole blood transcriptional responses to radiation-attenuated <em>Plasmodium falciparum</em> sporozoite vaccination in malaria naive and malaria... (Publications)
radiation-attenuated P. falciparum sporozoites were analysed and compared across malaria-naive adult participants (IMRAS) and malaria-experienced adult participants (BSPZV1). Parasite dose and method of delivery [...] despite stark differences between the two studies, including route of vaccination and status of malaria exposure, responses were identified that were associated with protection after PfRAS vaccination
The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control... (Publications)
sufficient for malaria elimination. The effects of community-based house improvement (HI) and larval source management (LSM) as supplementary interventions to the Malawi National Malaria Control Programme [...] tion indicated a promising reduction in malaria transmission for the area, but also limited the usefulness of this outcome for measuring differences in malaria transmission among the trial arms. Trial [...] bed net use, neither community-based HI, LSM, nor HI + LSM contributed to further...
OpenMalaria Workflow and OpenMalariaUtilities R Packages (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/openmalaria-workflow-and-openmalariautilities-r-packages
Swiss TPH GitHub . OpenMalariaUtilities R Package At the core of our OpenMalaria Workflow is the OpenMalariaUtilities R package which is developed to allow the use of OpenMalaria directly from R. The package [...] OpenMalaria Workflow R Package The work of the Analytics and Intervention Modelling Group is based on OpenMalaria : an open-source C++ program for simulating malaria epidemiology and the impacts on that [...] TPH GitHub. The OpenMalaria Workflow R Package together with the OpenMalariaU...