Made-to-measure malaria vector control strategies: rational design based on insecticide properties and coverage of blood resources for mosquitoes (Publications)
Eliminating malaria from highly endemic settings will require unprecedented levels of vector control. To suppress mosquito populations, vector control products targeting their blood hosts must attain high
The contribution of reduction in malaria as a cause of rapid decline of under-five mortality: evidence from the Rufiji Health and Demographic... (Publications)
settings. Malaria-related mortality is known to be a major component of childhood causes of death and malaria remains a major focus of health interventions. The paper explored the contribution of malaria relative [...] remained the leading cause of death for neonates, malaria remains as the leading cause of death for post-neonates followed by pneumonia. However, declines in malaria death rates accounted for 49.9% of the observed [...] accounted for only 19.9%. CONCLUSION: To achieve MDG 4 in mal...
Increasing role of <em>Anopheles funestus</em> and <em>Anopheles arabiensis</em> in malaria transmission in the Kilombero Valley, Tanzania (Publications)
order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This [...] This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contribution to malaria transmission in hyperendemic transmission settings in Tanzania. METHODS: The study was [...] arabiensis susceptibility to insecticides was assessed using WHO guidelines....
Potential causes and consequences of behavioural resilience and resistance in malaria vector populations: a mathematical modelling analysis (Publications)
evade fatal exposure to insecticidal nets and sprays represents the primary obstacle to eliminating malaria. However, it remains unclear which behaviours are most important for buffering mosquito and parasite
Improving health worker adherence to malaria treatment guidelines in Papua New Guinea: feasibility and acceptability of a text message reminder... (Publications)
whether a text message reminder service designed to support health worker adherence to a revised malaria treatment protocol is feasible and acceptable in Papua New Guinea (PNG). The study took place in [...] resources. In conclusion, a text message reminder service to support health worker adherence to the new malaria treatment protocol is feasible and acceptable in PNG. A rigorous pragmatic, effectiveness trial would
Efficacy and safety of dihydroartemisinin-piperaquine for treatment of <em>Plasmodium vivax</em> malaria in endemic countries: meta-analysis of... (Publications)
the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries. METHODOLOGY AND PRINCIPAL FINDINGS: This is a meta-analysis [...] Findings document that DHP is more efficacious than CQ and AL in treating uncomplicated P. vivax malaria. The better safety profile of DHP and the once-daily dosage improves adherence, and its fixed co [...] the potential to become an alternative antimalarial drug for the treatment...
Comparative assessment of diverse strategies for malaria vector population control based on measured rates at which mosquitoes utilize targeted... (Publications)
BACKGROUND: Eliminating malaria requires vector control interventions that dramatically reduce adult mosquito population densities and survival rates. Indoor applications of insecticidal nets and sprays
Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young... (Publications)
BACKGROUND: A malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at [...] at 11 African sites with varying malaria transmission. METHODS AND FINDINGS: 6,537 infants aged 6-12 wk and 8,923 children aged 5-17 mo were randomized to receive three doses of RTS,S/AS01 or comparator [...] comparator vaccine. VE against clinical malaria in children during the 18 mo after...
Institutional evolution of a community-based programme for malaria control through larval source management in Dar es Salaam, United Republic of... (Publications)
BACKGROUND: Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) program
Orally active antischistosomal early leads identified from the open access malaria box (Publications)
drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro [...] respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry