Collaboration on Malaria drug discovery (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/collaboration-on-malaria-drug-discovery
The goal of this collaborative project with Actelion Pharmaceuticals is the discovery of new antimalarial molecules with unknown mechanism(s) of action. Cell-based antimalarial screens were performed
Drug discovery for malaria based on novel drug targets in the NGBS Consortium (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/drug-discovery-for-malaria-based-on-novel-drug-targets-in-the-ngbs-consortium
The NGBS programme in malaria drug discovery is a collaboration between the Novartis Institute for Tropical Diseases (NITD), the Genomics Institute of the Novartis Research Foundation (GNF), the Biomedical [...] programme aims at solving two fundamental medical needs. Firstly, a one dose cure for P. falciparum malaria would be a breakthrough in solving compliance problems, and would also contribute easing logistical [...] NITD609 is the first molecule from a novel class of antimalarials to enter...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Diagnostic de malaria chez le praticien: comment gérer (Publications)
Malaria is the disease to exclude when dealing with a patient coming back from an endemic area with fever. We need reliable diagnostic tools with negative likelihood ratio (LR-) close to zero (-> high [...] 08 (estimated in a meta-analysis of RDT in non-immune travelers), the probability of falciparum malaria is 1% after a negative RDT. When the RDT is positive, the patient should always be treated with an
Meta-analysis: accuracy of rapid tests for malaria in travelers returning from endemic areas (Publications)
PURPOSE: To determine the accuracy of rapid diagnostic tests for ruling out malaria in nonimmune travelers returning from malaria-endemic areas. DATA SOURCES: The authors searched MEDLINE, EMBASE, CAB Health [...] diagnosis of P. malariae or P. ovale were close to 1.0 for both types of tests. In febrile travelers returning from sub-Saharan Africa, the typical probability of P. falciparum malaria is estimated at [...] of rapid diagnostic tests improves outcomes in returning travelers with...
