The time-course of protection of the RTS,S vaccine against malaria infections and clinical disease (Publications)
BACKGROUND: Recent publications have reported follow-up of the RTS,S/AS01 malaria vaccine candidate Phase III trials at 11 African sites for 32 months (or longer). This includes site- and time-specific [...] Bayesian fitting of these model predictions to the site- and time-specific incidence of clinical malaria over 32 months (or longer) of follow-up. Using the same stochastic models, projections of clinical
Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea (Publications)
BACKGROUND: The major malaria vectors of Papua New Guinea exhibit heterogeneities in distribution, biting behaviour and malaria infection levels. Long-lasting, insecticide-treated nets (LLINs), distributed [...] distributed as part of the National Malaria Control Programme, are the primary intervention targeting malaria transmission. This study evaluated the impact of LLINs on anopheline density, species composition [...] n, feeding behaviour, and malaria transmission. METHODS: Mosquitoes were...
Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d'Ivoire (Publications)
epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts. In Cote d'Ivoire, new initiatives are underway to reduce the burden of malaria, which [...] which requires high-quality longitudinal data. The epidemiology of malaria was studied in the Taabo health and demographic surveillance system (HDSS) in south-central Cote d'Ivoire and implications for control [...] 6 and 62.8 % versus 42.6 and 51.2 %; respectively, in 2010 and 2011;...
Endlich: Die Malaria-Impfung kommt [TV Broadcast] (Publications)
"Bill Gates selbst gibt am Gates Malaria Forum in Seattle die bahnbrechende Nachricht bekannt: Erstmals im 100-jährigen Kampf gegen Malaria kann die Registrierung eines Impfstoffs eingeleitet werden. Schon [...] Schon bald können also Säuglinge in Malaria-Gebieten routinemässig gegen den lebensbedrohlichen Erreger geimpft und Millionen Menschenleben gerettet werden. Einer freut sich besonders über den Durchbruch: [...] Durchbruch: Der Schweizer Marcel Tanner, unermüdlicher Kämpfer gegen Malaria...
Basel gegen Malaria : hinter den Kulissen der grössten humanitären Aktion der Schweiz [TV Broadcast] (Publications)
"Basel im Kampf gegen Malaria. Die humanitären Leistungen der letzten Jahre aus Basel im Kampf gegen Malaria stellen alle schweizerischen Anstrengungen für Menschen im zweiten Weltkrieg in den Schatten [...] Tropenkrankheit ist längst nicht ausgestanden. Noch immer sterben jährlich eine Million Menschen an Malaria. Der neue Report widmet sich einer der grössten humanitären Erfolgsgeschichten der Schweiz."
Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea (Publications)
multi-component malaria control intervention significantly reduced the prevalence of malaria in the sous-prefectures of intervention while also increasing the coverage of bed nets. However, malaria prevalence [...] BACKGROUND: Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions. To assist in malaria control efforts, a multi-component [...] nent malaria control intervention was implemented in the hyperendemic...
The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a... (Publications)
BACKGROUND: Iron deficiency (ID) and malaria co-exist in tropical regions and both contribute to high rates of anaemia in young children. It is unclear whether iron fortification combined with intermittent [...] intermittent preventive treatment (IPT) of malaria would be an efficacious strategy for reducing anaemia in young children. METHODS: A 9-month cluster-randomised, single-blinded, placebo-controlled intervention [...] out in children aged 12-36 months in south-central Cote d'Ivoire, an...
Health worker compliance with a 'test and treat' malaria case management protocol in Papua New Guinea (Publications)
current/recently febrile patients for malaria infection by RDT or microscopy in the absence of acute malaria symptoms, reserving recommended antimalarials for confirmed malaria cases only and choosing to clinically [...] Across the two surveys, 77.6% of patients were tested for malaria infection by rapid diagnostic test (RDT) or microscopy, 65.6% of confirmed malaria cases were prescribed the correct antimalarials and 15 [...] The Papua New Guinea (PNG) Department of Health introduced a 'test...
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
rheumatoid arthritis indicates that it could be safe and efficacious for treating malaria. We sought to establish a murine malaria model to study the mechanism of action and resistance of MTX and its analogue [...] receptor/transport to gain access to cells, their lack of efficacy against the four tested murine malaria species may be the result of inefficiency of drug transport
Synthetic GPI array to study antitoxic malaria response (Publications)
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI [...] on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria