Der lange Weg zur ersten Impfung gegen Malaria (Publications)
langen Weg: Die Weltgesundheitsorganisation hat jüngst den Einsatz des ersten Impfstoffes gegen Malaria zum breitflächigen Einsatz bei Kindern in den betroffenen Ländern empfohlen. Dennoch braucht es
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study (Publications)
ted BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults. CONCLUSIONS: A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African [...] we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients. RESULTS: RTS,S/AS01 vaccination was associated [...] month 3 levels correlated with malaria risk. In contrast, baseline levels...
Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites [...] vivo. These observations suggest that therapeutic interventions may promote gametocytogenesis and malaria transmission. Here, we engineered a P. falciparum reporter line to quantify sexual commitment rates [...] rates after exposure to antimalarials and other pharmaceuticals commonly...
Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)
targeted reductions in malaria prevalence. METHODS: A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering [...] mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve [...] achieve specified health goals. RESULTS: We apply our approach to five malar...
The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)
diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular method of measuring the survival and dispersal of disease vectors; however, examples with African malaria vectors are [...] This study demonstrates the successful use of a self-marking device in an MMRR study with African malaria vectors. This method may be useful in investigating population structure and dispersal of mosquitoes
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on [...] Altogether, these findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection.
Sex: how malaria parasites get turned on (Publications)
initiation of this cell fate decision, ultimately providing the malaria community with a novel and important tool in the battle to prevent malaria transmission.
Malaria: «Einstein» und die Spritze der Hoffnung (Publications)
In Afrika läuft die weltweit erste Impfkampagne gegen Malaria. In Ghana, Malawi und Kenia werden bis 2022 gegen zwei Millionen Kleinkinder mit dem Vakzin «RTS’S» geimpft. «Einstein» hat die Entwicklung [...] begleitet. Die Langzeit-Dokumentation zeigt auf, wie schwierig der Weg zur ersehnten neuen Waffe gegen Malaria war. Die Schweiz spielte bei der Entwicklung des Impfstoffs eine tragende Rolle, doch die Testreihen [...] und echte Forschungspartnerschaft zwischen Nord und Süd möglich war. Die...