Performance of antigen detection for HRP2-based malaria rapid diagnostic tests in community surveys: Tanzania, July-November 2017 (Publications)
BACKGROUND: Malaria rapid diagnostic tests (RDTs) based on the detection of the Plasmodium falciparum histidine-rich protein 2 (HRP2) antigen are widely used for detection of active infection with this [...] this parasite and are the only practical malaria diagnostic test in some endemic settings. External validation of RDT results from field surveys can confirm appropriate RDT performance. METHODS: A community-based [...] sites can help interpret RDT testing results when generating population...
The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania (Publications)
BACKGROUND: Current efforts to estimate the spatially diverse malaria burden in malaria-endemic countries largely involve the use of epidemiological modelling methods for describing temporal and spatial [...] adopted by the malaria programme in Tanzania. It makes use of available routine data that are rich in spatial resolution and that can be readily accessed allowing for a stratification of malaria risk below [...] optimal for supporting evidence-based, decentralized malaria control planning,...
Stratification of malaria incidence in Papua New Guinea (2011–2019): contribution towards a sub-national control policy (Publications)
Malaria risk in Papua New Guinea (PNG) is highly heterogeneous, between and within geographical regions, which is operationally challenging for control. To enhance targeting of malaria interventions in [...] Incidence maps show a contrast in malaria risk between coastal and inland areas influenced by altitude. However, the risk is highly variable in low-lying areas. Malaria interventions should be guided by [...] in PNG, we investigated risk factors and stratified malaria incidence at the level...
The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility (Publications)
Malaria persists at low levels on Zanzibar despite the use of vector control and case management. We use a metapopulation model to investigate the role of human mobility in malaria persistence on Zanzibar [...] parameterized using survey data on malaria prevalence, reactive case detection, and travel history. We find that in the absence of imported cases from mainland Tanzania, malaria would likely cease to persist [...] rapid diagnostic tests, a low rate of those infected with malaria seeking...
Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)
BACKGROUND: Rectal artesunate, an efficacious pre-referral treatment for severe malaria in children, was deployed at scale in Uganda, Nigeria, and DR Congo. In addition to distributing rectal artesunate [...] tion required additional investments in crucial but neglected components in the care for severe malaria. We examined the real-world costs and constraints to rectal artesunate implementation. METHODS: We [...] annual cost of rectal artesunate implementation per child younger than 5 years at...
A review of malaria epidemiology and control in Papua New Guinea 1900 to 2021: progress made and future directions (Publications)
been four major periods of malaria control in PNG, with the current control programme having commenced in 2004. Each previous control programme was successful in reducing malaria burden in the country, but [...] al drivers of malaria transmission in PNG. Evaluations of historical control programs reveal poor planning and communication, and di culty in sustaining financial investment once malaria burden had decreased [...] The research and control of malaria has a long history in Papua New...
Accelerated development of malaria monoclonal antibodies (Publications)
healthy adults.(1) These promising results are the first of many to usher in a potential new era of malaria prevention.
Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and <em>in vivo</em> efficacy in a... (Publications)
Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue 1 with an associated metabolic instability liability led to the identification of a highly potent 3-trifluor
New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies (Publications)
MMV’s Malaria Box compound MMV030666 shows multi-stage activity against various strains of Plasmodium falciparum and lacks resistance development. To evaluate the importance of its diarylether partial