Searched for malaria.

1. The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)

   The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed volunteers

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   The present project aimed at evaluating the safety and immunogenicity of P27A peptide vaccine in malaria non-exposed European and exposed African adults. Methods: This study was designed as a staggered [...] GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed and 40 exposed subjects on days 0, 28 and 56. Local and systemic adverse events (AEs) [...] an ADCI dependent mechanism. Incidence of AEs and antibody responses were...

2. UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria (Publications)

   UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria

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   drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, [...] single-exposure radical cure and prophylaxis (SERCaP) to treat, prevent and block the transmission of malaria.

3. Defining malaria risk: it is not only about epidemiology but also about perception and risk threshold of travellers and policy makers (Publications)

   Defining malaria risk: it is not only about epidemiology but also about perception and risk threshold of travellers and policy makers

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4. Evaluating the impact of individual, social, and environmental factor on bed net use for malaria prevention (Publications)

   Evaluating the impact of individual, social, and environmental factor on bed net use for malaria prevention

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5. Malaria and the 'last' parasite: how can technology help? (Publications)

   Malaria and the 'last' parasite: how can technology help?

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   Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges [...] accurate detection of malaria infections, both in symptomatic and asymptomatic individuals are needed. In this review, the current progress in developing new diagnostic tools to fight malaria is presented. An [...] An ideal rapid test for malaria elimination is envisioned with examples...

6. Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)

   Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies

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   antibodies are induced following immunization of malaria pre-exposed volunteers with PfSPZ Vaccine. We found that in addition to anti-PfCSP IgG, Malaria pre-exposed volunteers developed anti-PfCSP IgM [...] and Pf sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria pre-exposed individuals and that IgM antibodies can inhibit Pf sporozoite invasion into hepatocytes

7. Development of stage-specific detection assays for <em>P.malariae </em>and <em>P.ovale</em> gametocytes and development of a <em>P.vivax</em> assay... (Publications)

   Development of stage-specific detection assays for <em>P.malariae </em>and <em>P.ovale</em> gametocytes and development of a <em>P.vivax</em> assay targeting multi-copy genomic sequences

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8. Challenges in malaria management and a glimpse at some nanotechnological approaches (Publications)

   Challenges in malaria management and a glimpse at some nanotechnological approaches

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   formulate a potent malaria vaccine need to be addressed with new strategies to achieve the final goal of malaria eradication. Nanotechnology-researching and designing innovative structures at the nanoscale-is [...] the case of malaria, nanotechnology provides tools to design strategies to target drug molecules to specific stages of the parasite, treat drug-resistant parasites, resolve severe malaria, increase vaccine [...] vaccine efficacies and combinations thereof. This chapter introduces mala...

9. Towards protective immune responses against malaria in pregnant women (Publications)

   Towards protective immune responses against malaria in pregnant women

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10. Malaria elimination transmission and costing in the Asia-Pacific: developing an investment case (Publications)

    Malaria elimination transmission and costing in the Asia-Pacific: developing an investment case

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    the regional goal of malaria elimination by 2030 will require an intensification of efforts and a plan for sustainable financing. This article presents an investment case for malaria elimination to facilitate [...] billion. Malaria elimination provides a 6:1 return on investment. Conclusion: This investment case provides compelling evidence for the benefits of continued prioritization of funding for malaria and can [...] Background: The Asia-Pacific region has made significant progress against m...