Exploring early sexual differentiation in the malaria parasite Plasmodium falciparum (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/exploring-early-sexual-differentiation-in-the-malaria-parasite-plasmodium-falciparum
Apicomplexa, is the causative agent of the most severe form of malaria in humans. Despite the massive implementation of control interventions, malaria still causes over 200 million clinical cases and half a million [...] million deaths annually. The widespread prevalence of malaria in endemic regions is maintained by a complex yet highly efficient transmission cycle between the human host and mosquito vector. For transmission [...] gametocyte biology will be essential to support the development...
Combining sociological, economic and epidemiological evidence to target malaria interventions in Papua New Guinea and beyond (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/combining-sociological-economic-and-epidemiological-evidence-to-target-malaria-interventions-in-papua-new-guinea-and-beyond
interventions. However, current recommendations focus exclusively on stratification by malaria risk. Yet, malaria is multi-factorial and the impact of interventions in a given setting also depends on [...] conceptual framework for a multi-dimensional malaria stratification beyond mere epidemiological indicators. Papua New Guinea (PNG) with its complex malaria epidemiology serves as a model country. Project [...] To improve the (cost-) effectiveness of malaria control and accelerate progress...
Environmental, Social, Economic and Health Impact Assessment (ESHIA) for a Field Study of a Self-Limiting Nondrive Strain of Genetically Modified... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/environmental-social-economic-and-health-impact-assessment-eshia-for-a-field-study-of-a-self-limiting-nondrive-strain-of-genetically-modified-mosquitoes-on-behalf-of-target-malaria
Genetically modified mosquitoes (GMMs) represent great potential for malaria control in the future. Target Malaria – a vector control research alliance based at the Imperial College in London – aims to [...] develop genetic technologies to modify mosquitoes with the ultimate goal to reduce malaria transmission. Target Malaria uses a three-phased approach in this 170-million project funded by the Bill and Melinda
Correction to: Methods and indicators for measuring patterns of human exposure to malaria vectors (Publications)
An amendment to this paper has been published and can be accessed via the original article.
Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults (Publications)
(Pf) sporozoites (PfSPZ Vaccine) and protective efficacy assessed by homologous controlled human malaria infection (CHMI). Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf [...] first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2,239 functionally diverse Pf proteins
Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa (Publications)
of the age- and season- dependence of malaria mortality is an important prerequisite for epidemiologic models of malaria immunity. However, most studies of malaria mortality have aggregated their results [...] stable endemic Plasmodium falciparum malaria. We use verbal autopsies (VAs) to estimate the proportion of deaths by age group due to malaria, and thus calculate malaria-specific mortality rates for each site [...] attributed to malaria. The overall age patterns of malaria mortality were...
Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa (Publications)
of the age- and season- dependence of malaria mortality is an important prerequisite for epidemiologic models of malaria immunity. However, most studies of malaria mortality have aggregated their results [...] stable endemic Plasmodium falciparum malaria. We use verbal autopsies (VAs) to estimate the proportion of deaths by age group due to malaria, and thus calculate malaria-specific mortality rates for each site [...] attributed to malaria. The overall age patterns of malaria mortality were...
Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/multi-scale-mathematical-modelling-of-parasite-drug-and-vaccine-interactions-optimising-public-health-and-disease-elimination-strategies
are best able to reduce and halt malaria transmission. Mathematical modelling can help understand malaria dynamics and interactions between malaria tools and the malaria parasite, human and mosquito hosts [...] been made over the last decades in controlling malaria. From 2000 to 2015 scale-up of control and curative interventions enabled a 60% reduction in malaria death rates and a 40% reduction in rate of clinical [...] disease. Despite these gains, we face significant challenges if we are to...
Human unconventional T cells in <em>Plasmodium falciparum</em> infection (Publications)
field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less [...] tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement [...] Malaria is an old scourge of humankind and has a large negative impact...
Human unconventional T cells in <em>Plasmodium falciparum</em> infection (Publications)
field of malaria immunology. Significant advances in our basic understanding of unconventional T cell biology in rodent malaria models have been made, however, their roles in humans during malaria are less [...] tissues, and long-lasting expansions and functional alterations were observed upon malaria infection in malaria naïve and malaria pre-exposed volunteers. Here, we review the current understanding of involvement [...] Malaria is an old scourge of humankind and has a large negative impact...