Distribution of survival times of deliberate <em>Plasmodium falciparum</em> infections in tertiary syphilis patients (Publications)
has important implications for mathematical modelling of malaria, which has for the past century exclusively assumed that the duration of malaria infections has an exponential distribution. It is desirable [...] influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria
Disruption of erythrocyte rosettes and agglutination of erythrocytes infected with<em> Plasmodium falciparum</em> by the sera of Papua New Guineans (Publications)
Antibodies disrupting erythrocyte rosettes have been associated with protection against cerebral malaria, and antibodies agglutinating infected erythrocytes with reduced episodes of clinical disease. We [...] have studied the capacity of serum from Papua New Guinean adults and children with a spectrum of malaria exposure, including children and adults at the time of clinical disease, to disrupt erythrocyte rosettes [...] Rosette disrupting antibodies were equally frequent in children with...
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound should be further developed and may contribute to malaria control and eradication as part of a single-dose [...] As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs [...] we found that the derivative, MMV390048, lacked cross-resistance with current drugs...
The N-terminal domain of <em>Plasmodium falciparum</em> circumsporozoite protein represents a target of protective immunity (Publications)
serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS(65-110)) by sera from children living in a malaria-endemic region was associated with [...] N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice [...] from disease. Taken together, these results underline the...
The N-terminal domain of <em>Plasmodium falciparum</em> circumsporozoite protein represents a target of protective immunity (Publications)
serum samples from people living in malaria-endemic regions. Importantly, recognition of the short N-terminal peptide (PfCS(65-110)) by sera from children living in a malaria-endemic region was associated with [...] N-terminal domain of the circumsporozoite protein (CSP) has been largely neglected in the search for a malaria vaccine in spite of being a target of inhibitory antibodies and protective T cell responses in mice [...] from disease. Taken together, these results underline the...
Antimalarial efficacy of MMV390048, an inhibitor of <em>Plasmodium</em> phosphatidylinositol 4-kinase (Publications)
of MMV390048 to block all life cycle stages of the malaria parasite suggests that this compound should be further developed and may contribute to malaria control and eradication as part of a single-dose [...] As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs [...] we found that the derivative, MMV390048, lacked cross-resistance with current drugs...
Disruption of erythrocyte rosettes and agglutination of erythrocytes infected with<em> Plasmodium falciparum</em> by the sera of Papua New Guineans (Publications)
Antibodies disrupting erythrocyte rosettes have been associated with protection against cerebral malaria, and antibodies agglutinating infected erythrocytes with reduced episodes of clinical disease. We [...] have studied the capacity of serum from Papua New Guinean adults and children with a spectrum of malaria exposure, including children and adults at the time of clinical disease, to disrupt erythrocyte rosettes [...] Rosette disrupting antibodies were equally frequent in children with...
Repellents and new "spaces of concern" in global health (Publications)
Today, malaria prevention hinges upon two domestic interventions: insecticide-treated bed nets and indoor residual spraying. As mosquitoes grow resistant to these tools, however, novel approaches to vector [...] vector control have become a priority area of malaria research and development. Spatial repellency, a volumetric mode of action that seeks to reduce disease transmission by creating an atmosphere inimical [...] of a non-insecticidal paradigm of vector control for how we understand the...
Repellents and new "spaces of concern" in global health (Publications)
Today, malaria prevention hinges upon two domestic interventions: insecticide-treated bed nets and indoor residual spraying. As mosquitoes grow resistant to these tools, however, novel approaches to vector [...] vector control have become a priority area of malaria research and development. Spatial repellency, a volumetric mode of action that seeks to reduce disease transmission by creating an atmosphere inimical [...] of a non-insecticidal paradigm of vector control for how we understand the...
Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children (Publications)
drug regimen at US$67.77 (61.71-74.75, CI 95%) per malaria case averted based on intervention costs only, US$64.93 (58.92-71.92, CI 95%) per malaria case averted once the provider cost savings are included [...] and AS & AQ bimonthly US$211.80 (127.05-399.14, CI 95%) per malaria case averted based on intervention costs only. The incidence of malaria in the post intervention period was higher in children who were [...] BACKGROUND: Intermittent preventive treatment for malaria in children (IPTc)...