<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
Nicolas Brancucci (People)
https://www.swisstph.ch/en/staff/profile/people/nicolas-brancucci
TPH to establish new drug screening approaches and to search for malaria transmission-blocking drugs. Since 2020, he is leading the “Malaria Host Interactions” research unit at the Swiss THP and holds a [...] Brancucci is a parasitologist particularly interested in studying molecular interactions between malaria parasites and their human host cells. In current projects, his team studies nutrient sensing and
<em>Ex vivo</em> interferon-gamma immune response to thrombospondin-related adhesive protein in coastal Kenyans: longevity and risk of <em>Plasmodium... (Publications)
against the subsequent development of malaria. Retesting of selected donors after one year showed a complete change in the reactivity pattern, suggesting that malaria-specific ex vivo IFN-gamma ELISPOT assay [...] conserved epitopes. This study provides important information regarding natural reactivity to a key malaria antigen
Detection of antibodies to <em>Plasmodium falciparum</em> sporozoites by employing synthetic peptides (Publications)
A new achievement in the immunodiagnosis of malaria has been reached after the knowledge of the molecular structure of some plasmodial antigens has become available. One example is given by the repetitive [...] immunosorbent assay (ELISA) for the detection of antisporozoite antibodies in individuals from malaria-endemic countries. This (NANP)40 ELISA has been employed in a longitudinal study in a rural community [...] and can be useful for monitoring the immune status of populations...
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (Publications)
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor [...] Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient to cure a malaria infection in humans. Toxicology studies in rats indicate a > 30-fold safety margin in relation to [...] promising candidate for further (pre)clinical development with a novel...
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
were obtained from the 2011 Demographic and Health Survey, while data on malaria prevalence were extracted from the 2009 Malaria Indicator Survey. Bayesian geostatistical Weibull proportional hazards models [...] five years in Uganda were attributable to malaria, severe/moderate anaemia, severe/moderate malnutrition and diarrhoea respectively. The attribution of malaria was comparable in Central 2, East-Central [...] used household surveys to quantify the effects and contribution of main...
The effects and contribution of childhood diseases on the geographical distribution of all-cause under-five mortality in Uganda (Publications)
were obtained from the 2011 Demographic and Health Survey, while data on malaria prevalence were extracted from the 2009 Malaria Indicator Survey. Bayesian geostatistical Weibull proportional hazards models [...] five years in Uganda were attributable to malaria, severe/moderate anaemia, severe/moderate malnutrition and diarrhoea respectively. The attribution of malaria was comparable in Central 2, East-Central [...] used household surveys to quantify the effects and contribution of main...
Our exciting journey to ACT-451840 (Publications)
broadly characterized in vitro as well as in vivo in rat PK experiments as well as two different mouse malaria models. In the P. berghei infected mouse model cure could be achieved at oral doses of 300 mg/kg [...] mg/kg over 3 consecutive days. ACT-451840 was clinically investigated up to an experimental human malaria infection model, where therapeutic effects could be shown.
Our exciting journey to ACT-451840 (Publications)
broadly characterized in vitro as well as in vivo in rat PK experiments as well as two different mouse malaria models. In the P. berghei infected mouse model cure could be achieved at oral doses of 300 mg/kg [...] mg/kg over 3 consecutive days. ACT-451840 was clinically investigated up to an experimental human malaria infection model, where therapeutic effects could be shown.
Health facility-based data on women receiving sulphadoxine-pyrimethamine during pregnancy in Tanzania: lessons to learn from a cross-sectional survey... (Publications)
data on women receiving sulphadoxine-pyrimethamine (SP) for intermittent preventive treatment of malaria during pregnancy (IPTp) was carried out at antenatal care clinics in Mkuranga and Mufindi districts [...] system (HMIS) registers, interviews with health-care workers (HWs) and district and national level malaria control program managers corroborated by inter-temporal assessment through observations at HF levels [...] measures are urgently needed to accommodate data on new interventions and...