Synthesis of szentiamide, a depsipeptide from entomopathogenic <em>Xenorhabdus szentirmaii</em> with activity against <em>Plasmodium falciparum</em> (Publications)
on of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria
SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols (Publications)
tested for their activity against the causative organisms of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed
SARs of the antiprotozoal action of 6,7-diaryl-bicyclo[2.2.2]octan-2-ols (Publications)
tested for their activity against the causative organisms of East African sleeping sickness and malaria tropica. Structure activity relationships are discussed
Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya (Publications)
study investigates the experience of caregivers consenting on behalf of paediatric participants in a malaria vaccine clinical trial where participation enables access to free, high-quality medical care. METHODS: [...] interviewed a total of 78 caregivers of paediatric participants previously enrolled in a phase II or III malaria vaccine clinical trial in Uganda, Tanzania and Kenya. Interviews were qualitative and analysed using
Can trials of spatial repellents be used to estimate mosquito movement? (Publications)
Knowledge of mosquito movement would aid the design of effective intervention strategies against malaria. However, data on mosquito movement through mark-recapture or genetics studies are challenging to [...] method may supplement those from mark-release-recapture studies, and be used in designing effective malaria intervention strategies, parameterizing mathematical models and in designing trials of vector control
Prevalence and determinants of undernutrition in schoolchildren in the Kilombero district, South-Eastern Tanzania (Publications)
wasting, and underweight, while logistic regression analyses examined sociodemographic background, malaria infection, anaemia, anthropometric measures, and dietary diversity score as potential factors. The [...] obesity was 11.8%, 4.3%, 3.9%, 11.1%, and 2.0%, respectively. Overall, 1.5% of the children had malaria, as determined by rapid diagnostic tests, and 0.4% had severe anaemia. Univariate analysis indicated
Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker (Publications)
sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone to resistance and require parenteral administration. Malaria is responsible
Detection of <em>Plasmodium falciparum</em> infected <em>Anopheles gambiae</em> using near‑infrared spectroscopy (Publications)
demonstrates proof-of-concept that NIRS is capable of rapidly identifying laboratory strains of human malaria infection in African mosquito vectors. CONCLUSIONS: Accurate, low-cost, reagent-free screening of [...] by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species. Further research is needed to evaluate how the method
PHARE: a bioinformatics pipeline for compositional profiling of multiclonal <em>Plasmodium falciparum</em> infections from long-read Nanopore... (Publications)
detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic settings, malaria infected people often carry multiple P. falciparum clones simultaneously
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to <em>Plasmodium</em> (Publications)
Current malaria therapeutics demands strategies able to selectively deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly [...] , and selective internalization into pRBCs but not in healthy erythrocytes for human and rodent malarias, may be regarded as promising candidates deserving to enter the antimalarial therapeutic arena.