Searched for malaria.

1. Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)

   Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter]

   Relevance:

   Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those children

2. Diaryl ureas as an antiprotozoal chemotype (Publications)

   Diaryl ureas as an antiprotozoal chemotype

   Relevance:

   kinetic aq. solubilities were /=10. One N,N'-diarylurea had demonstrable activity in mouse models of malaria and toxoplasmosis.

3. Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter] (Publications)

   Blood transfusion for severe anaemia in children in a Kenyan hospital [Research letter]

   Relevance:

   Severe anaemia often secondary to malaria is a major contributor to child mortality in sub-Saharan Africa. We have confirmed that use of simple clinical and laboratory criteria can identify those children

4. A paradigm for Africa-centric vaccine development in Equatorial Guinea (Publications)

   A paradigm for Africa-centric vaccine development in Equatorial Guinea

   Relevance:

   The Equatorial Guinea Malaria Vaccine Initiative (EGMVI) highlights how long-term African government and international energy industry investment, plus novel partnerships, can enable clinical development

5. <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> genotypes and efficacy of intermittent preventive treatment in Papua New Guinea (Publications)

   <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> genotypes and efficacy of intermittent preventive treatment in Papua New Guinea

   Relevance:

   Intermittent preventive treatment of infants (IPTi) reduces early-childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial

6. L'efficacité c'est bien, l'impact c'est top! (Publications)

   L'efficacité c'est bien, l'impact c'est top!

   Relevance:

   our own experience is given to illustrate the reduction of the effect of an intervention against malaria in young children at different stages of the development of the intervention, and the parallel decrease

7. <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> genotypes and efficacy of intermittent preventive treatment in Papua New Guinea (Publications)

   <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> genotypes and efficacy of intermittent preventive treatment in Papua New Guinea

   Relevance:

   Intermittent preventive treatment of infants (IPTi) reduces early-childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial

8. L'efficacité c'est bien, l'impact c'est top! (Publications)

   L'efficacité c'est bien, l'impact c'est top!

   Relevance:

   our own experience is given to illustrate the reduction of the effect of an intervention against malaria in young children at different stages of the development of the intervention, and the parallel decrease

9. A Phase 2 interventional, multicenter, randomized, openlabel study in three age-descending cohorts to evaluate efficacy, safety and tolerability of... (Projects)

   A Phase 2 interventional, multicenter, randomized, openlabel study in three age-descending cohorts to evaluate efficacy, safety and tolerability of KAF156 and Lumefantrine-SDF combination in the treatment of acute uncomplicated Plasmodium falciparum Malar

   Relevance:
   https://www.swisstph.ch/en/projects/project-detail/project/a-phase-2-interventional-multicenter-randomized-openlabel-study-in-three-age-descending-cohorts-to-evaluate-efficacy-safety-and-tolerability-of-kaf156-and-lumefantrine-sdf-combination-in-the-treatment-of-acute-uncomplicated-plasmodium-falciparum-malar

   and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P. falciparum malaria (with or without other Plasmodium spp. co-infection).

10. Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)

    Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling

    Relevance:

    cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection [...] determination of the dose-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. CONCLUSION: The dual activity of ACT-451840