Mapping multiple components of malaria risk for improved targeting of elimination interventions (Publications)
component, related mappable malaria metrics are also described which may be measured and evaluated by malaria programmes seeking to better understand the determinants of malaria risk. Implementing tailored [...] There is a long history of considering the constituent components of malaria risk and the malaria transmission cycle via the use of mathematical models, yet strategic planning in endemic countries tends [...] tends not to take full advantage of available disease intelligence to tailor...
Impact of climate variability on the transmission risk of malaria in northern Côte d'Ivoire (Publications)
climate patterns might affect the transmission of malaria. The purpose of this study was to analyze climate and environmental parameters associated with malaria transmission in Korhogo, a city in northern Cote [...] (95% CI: 0.1 to 6.7%) in clinical malaria episodes. A 0.1 unit increase in monthly NDVI was associated with a 7.3% (95% CI: 0.8 to 14.1%) increase in the monthly malaria count. There was a similar increase [...] 2.3% to 11.2%)). The study results can be used to establish a malaria...
Mathematical modelling of the impact of expanding levels of malaria control interventions on <em>Plasmodium vivax</em> (Publications)
Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies
Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania (Publications)
data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within countries is increasing, and the available malaria control tools are expanding while large [...] the revision of the national malaria strategic plan with interventions targeted to the malaria risk at the sub-regional level. As part of the revision, a mathematical malaria modelling framework for setting [...] study article describes the long-term use of modelling in close collaboration...
Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A (Publications)
novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria unexposed adults [...] adults in Switzerland and in malaria pre-exposed adults in Tanzania, P27A formulated with Alhydrogel and GLA-SE adjuvants induced antigen-specific antibodies and T-cell activity. The GLA-SE adjuvant induced
Long-lasting insecticidal nets retain bio-efficacy after 5 years of storage: implications for malaria control programmes (Publications)
nets (LLINs) are the most sustainable and effective malaria control tool currently available. Global targets are for 80% of the population living in malaria endemic areas to have access to (own) and use a [...] manufacturer's recommended conditions may be optimally effective against Anopheles mosquitoes, to inform malaria control programmes and governments on the periods over which LLINs may be stored between distributions
Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization (Publications)
accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most clinically advanced malaria vaccine, has moderate efficacy in African children. In contrast, immunization with sporozoites under [...] cohorts and three African countries participating in an RTS,S/AS01E pediatric phase 3 trial and malaria-naïve individuals participating in a CPS trial. We identified both preimmunization and postimmunization