Flow cytometric analysis on cross-reactivity of human-specific CD monoclonal antibodies with splenocytes of <em>Aotus nancymaae</em>, a non-human... (Publications)
to explore complex host-pathogen interactions in non-human primate animal models, particularly in malaria vaccine research
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development
Evaluation of ethnobotanically selected Benin medicinal plants for their in vitro antiplasmodial activity (Publications)
Twenty extracts from nine Benin medicinal plants, traditionally used to treat malaria, were screened for in vitro antiplasmodial activity towards Plasmodium falciparum K1 chloroquine resistant and 3D7
Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selective
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the
South-East Asia (Publications)
reduced the prevalence of parasitic diseases, but the emergence and spread of artemisinin-resistant malaria and multidrug-resistant (MDR) TB, along with the widespread use of often poor-quality anti-infective
Validation of the protein kinase <em>Pf</em>CLK3 as a multistage cross-species malarial drug target (Publications)
target for drugs, with the potential to offer a cure-to be prophylactic and transmission blocking in malaria.
Expression of the MSPDBL2 antigen in a discrete subset of <em>Plasmodium falciparum</em> schizonts is regulated by GDV1 but may not be linked to... (Publications)
requires further investigation in natural infections where it is under immune selection. IMPORTANCE: Malaria parasites in the blood are remarkably variable, able to switch antigenic targets so they may survive [...] developed specific immune responses. This is one of the challenges in developing vaccines against malaria. MSPDBL2 is a target of naturally acquired immunity expressed in minority proportions of schizonts
Predictive value of clinical and laboratory features for the main febrile diseases in children living in Tanzania: a prospective observational study (Publications)
also found: malaria could be ruled in by recent travel, typhoid by jaundice, radiological pneumonia by very fast breathing and UTI by fever duration of > /=4 days. The CART model for malaria included t
Comparison of molecular quantification of <em>Plasmodium falciparum</em> gametocytes by <em>Pfs</em>25 qRT-PCR and QT-NASBA in relation to mosquito... (Publications)
BACKGROUND: Quantifying gametocyte densities in natural malaria infections is important to estimate malaria transmission potential. Two molecular methods (Pfs25 mRNA quantitative reverse transcriptase