Mosquito nets and the poor: can social marketing redress inequities in access? (Publications)
Treated mosquito nets are a practical malaria control tool. However, implementation of efficient delivery mechanisms remains a challenge. We investigated whether social marketing of treated mosquito nets
TKK130 is a 3-hydroxy-propanamidine (HPA) with potent antimalarial <em>in vivo</em> activity and a high barrier to resistance (Publications)
Malaria continues to pose a significant burden on populations in endemic areas and requires innovative treatment options. Here, we report the synthesis and preclinical evaluation of the novel 3-hydrox
Anti-malarial ozonides OZ439 and OZ609 tested at clinically relevant compound exposure parameters in a novel ring-stage survival assay (Publications)
BACKGROUND: Drug efficacy against kelch 13 mutant malaria parasites can be determined in vitro with the ring-stage survival assay (RSA). The conventional assay protocol reflects the exposure profile of
Evidence that <em>Plasmodium falciparum</em> chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing... (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation through allelic exclusion and variant expression of surface proteins encoded by the var gene family. Regulation of var genes is
Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine... (Publications)
structurally diverse starting points for the development of chemotherapeutic agents for the treatment of malaria are urgently needed. Thus, a series of 20 adenosine derivatives with a large lipophilic substituent
Maurer's clefts, the enigma of <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum, the causative agent of malaria, completely remodels the infected human erythrocyte to acquire nutrients and to evade the immune system. For this process, the parasite exports more
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is the
A <em>Plasmodium </em>membrane receptor platform integrates cues for egress and invasion in blood forms and activation of transmission stages (Publications)
Critical events in the life cycle of malaria-causing parasites depend on cyclic guanosine monophosphate homeostasis by guanylyl cyclases (GCs) and phosphodiesterases, including merozoite egress or invasion
Helen Prytherch (People)
https://www.swisstph.ch/en/staff/profile/people/helen-prytherch
(GIZ), Swiss Agency for Development and Cooperation, World Health Organization and the Roll Back Malaria Partnership.
Pyrethroid and etofenprox resistance in <em>Anopheles gambiae </em>and <em>Anopheles coluzzii </em>from vegetable farms in Yaounde, Cameroon:... (Publications)
Previous studies have indicated widespread insecticide resistance in malaria vector populations from Cameroon. However, the intensity of this resistance and underlying mechanisms are poorly known. Therefore