Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled
A sero-epidemiological approach to explore transmission of <em>Mycobacterium ulcerans</em> (Publications)
Ghana were included in the study. While first serological responses to the mosquito transmitted malaria parasite Plasmodium falciparum and to soil transmitted Strongyloides helminths emerged around the
Assessing seasonal variations and age patterns in mortality during the first year of life in Tanzania (Publications)
trends. Mortality rates in Sub-Sahara Africa show seasonal patterns due to high infant and child malaria-related mortality which is influenced by seasonal features present in environmental and climatic
<em>Plasmodium vivax </em>molecular diagnostics in community surveys: pitfalls and solutions (Publications)
ial DNA-based assay increased prevalence from 4.9 to 6.5%. The usefulness of molecular tests in malaria epidemiological studies is widely recognized, especially when precise prevalence rates are desired
Antitrypanosomal activity of sesquiterpene lactones from <em>Helianthus tuberosus</em> L. including a new furanoheliangolide with an unusual structure (Publications)
(Chagas Disease), Leishmania donovani (Visceral Leishmaniasis) and Plasmodium falciparum (Tropical Malaria) as well as cytotoxicity against rat skeletal myoblasts (L6 cell line) was determined along with
Search for antiprotozoal activity in herbal medicinal preparations; new natural leads against neglected tropical diseases (Publications)
Sleeping sickness, Chagas disease, Leishmaniasis, and Malaria are infectious diseases caused by unicellular eukaryotic parasites ("protozoans"). The three first mentioned are classified as Neglected Tropical
Drug repurposing in the chemotherapy of infectious diseases (Publications)
attack that are divergent share common ancestry (e.g., prokaryotic targets in the apicoplast of malaria parasites), whereas those that are convergent arise from a shared lifestyle (e.g., the susceptibility
<em>Schistosoma</em>, other helminth infections, and associated risk factors in preschool-aged children in urban Tanzania (Publications)
and performed medical examinations. We performed full blood cell counts and screened for HIV and malaria. Point-of-care circulating cathodic antigen (POC-CCA), urine filtration, Kato-Katz, FLOTAC, and Baermann
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects (Publications)
functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management
Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em> (Publications)
donovani) and cytotoxicity against mammalian primary cells. The highest activity was exerted against the malaria parasite P. falciparum (IC50 value 0.65 mug/mL) with low cytotoxicity (IC50 value 56.6 mug/mL). To