Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African... (Publications)
resistance to pyrethroid insecticides is widespread in Anopheles mosquitoes and is a major threat to malaria control. DNA markers would aid predictive monitoring of resistance, but few mutations have been
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: antimicrobial evaluation and mechanistic insights (Publications)
activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. All compounds were active against the two strains, generally showing
Immune system development varies according to age, location, and anemia in African children (Publications)
Mozambique by detailed immunophenotyping of longitudinal blood samples collected during the RTS,S malaria vaccine phase 3 trial. In these cohorts, the composition of the immune system is dynamically transformed
Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania (Publications)
Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation
A potent and selective reaction hijacking inhibitor of <em>Plasmodium falciparum</em> tyrosine tRNA synthetase exhibits single dose oral efficacy... (Publications)
ML471 is well-tolerated and shows single dose oral efficacy in the SCID mouse model of P. falciparum malaria. We confirm that ML471 is a reaction hijacking inhibitor that is converted into a tight binding Tyr-ML471
Integral solvent-induced protein precipitation for target-engagement studies in <em>Plasmodium falciparum</em> (Publications)
mechanism of action (MoA) of several antimalarials and the rise of drug resistance toward existing malaria therapies emphasizes the need for new strategies to uncover the molecular target of compounds in
Molecular epidemiology and genetic diversity of disappearing <em>Plasmodium vivax</em> in southern Thailand (Publications)
The evolution of genetic diversity and population structure of Plasmodium vivax as malaria elimination approaches remains unclear. This study analyzed the genetic variation and molecular epidemiology of
3-Benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies (Publications)
activity of plasmodione and related analogues are potentially associated with these two organelles in malaria parasites.
Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)
e compounds. Some of the alkaloids of A. abbreviatus exhibited promising activities against the malaria parasite Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Setting priorities for knowledge translation of Cochrane reviews for health equity: evidence for equity (Publications)
with high burdens of disease globally, were selected for the pilot: diabetes/obesity, HIV/AIDS, malaria, nutrition, and mental health/depression. For each topic area, a "stakeholder panel" was assembled