A molecular marker of artemisinin-resistant <em>Plasmodium falciparum</em> malaria (Publications)
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular
Child mortality patterns in rural Tanzania: an observational study on the impact of malaria control interventions (Publications)
BACKGROUND: Between 1997 and 2009, a number of key malaria control interventions were implemented in the Kilombero and Ulanga Districts in south central Tanzania to increase insecticide-treated nets (ITN) [...] (ITN) coverage and improve access to effective malaria treatment. In this study we estimated the contribution of these interventions to observed decreases in child mortality. METHODS: The local Health and [...] security. We used Poisson regression with linear and segmented effects to...
Epigenetic memory takes center stage in the survival strategy of malaria parasites (Publications)
Malaria parasites run through a complex life cycle in the vertebrate host and mosquito vector. This not only requires tightly controlled mechanisms to govern stage-specific gene expression but also ne [...] sexual conversion and discuss the relevance of this strategy for the survival and transmission of malaria parasites.
Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa (Publications)
BACKGROUND: Anaemia is common in malaria. It is important to quantitate the risk of anaemia and to distinguish factors related to the natural history of disease from potential drug toxicity. METHODS: [...] data analysis based on nine randomized controlled trials of treatments of uncomplicated falciparum malaria from 13 sub-Saharan African countries. Risk factors for reduced haemoglobin (Hb) concentrations and