Cinnamoylphenethyl amides from <em>Polygonum hyrcanicum</em> possess anti-trypanosomal activity (Publications)
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the e
The contribution of spatial analysis to understanding HIV/TB mortality in children: a structural equation modelling approach (Publications)
Background: South Africa accounts for more than a sixth of the global population of people infected with HIV and TB, ranking her highest in HIV/TB co-infection worldwide. Remote areas often bear the g
Performance of multi-cities land use regression models for nitrogen dioxide and fine particles (Publications)
BACKGROUND: Land use regression (LUR) models have mostly been developed to explain intra-urban variations in air pollution based on often small local monitoring campaigns. Transferability of LUR model
Effects of vector-control interventions on changes in risk of malaria parasiotaemia in sub-Saharan Africa: a spatial and temporal analysis (Publications)
BACKGROUND: In the past decade, decreases in clinical episodes and deaths due to malaria have been mainly associated with the expansion of vector-control measures, such as insecticide-treated bednets
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity (Publications)
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma bru
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
Despite immense efforts to combat malaria in tropical and sub-tropical regions, the potency of this vector-borne disease and its status as a major driver of morbidity and mortality remain undisputed.
