Identification of antischistosomal leads by evaluating bridged 1,2,4,5-tetraoxanes, alphaperoxides, and tricyclic monoperoxides (Publications)
Although antischistosomal properties of peroxides were studied in recent years, systematic structure-activity relationships have not been conducted. We evaluated the antischistosomal potential of 64 p
Lack of antigenic diversification of major outer membrane proteins during clonal waves of <em>Neisseria meningitidis</em> serogroup A colonization and... (Publications)
In particular in the 'meningitis belt' of sub-Saharan Africa, epidemic meningococcal meningitis is a severe public health problem. In the past decades, serogroup A lineages have been the dominant etio
PM10 and children's respiratory symptoms and lung function in the PATY study (Publications)
Studies of the impact of long-term exposure to outdoor air pollution on prevalence of respiratory symptoms and lung function in children have yielded mixed results, partly related to differences in st
Synthesis and structure-activity relationships of new quinolone-type molecules against <em>Trypanosoma brucei</em> (Publications)
Human African trypanosomiasis (HAT) or sleeping sickness is caused by two subspecies of Trypanosoma brucei , Trypanosoma brucei gambiense , and Trypanosoma brucei rhodesiense and is one of Africa's ol
Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based... (Publications)
The pharmacogenetics of antimalarials is poorly known, although its application might be critical to optimize treatment. This population pharmacokinetic-pharmacogenetic study aimed at assessing the ef
Characterization of invasive and colonizing isolates of <em>Streptococcus agalactiae</em> in East African adults (Publications)
95 colonizing and 74 invasive Streptococcus agalactiae isolates from Kenyan adults were characterized using capsular serotyping and multilocus sequence typing. 22 sequence types clustering into five c