Antitrypanosomal triterpenoid with an epsilon-lactone E-ring from <em>Salvia urmiensis</em> (Publications)
A new triterpenoid, urmiensolide (1), was isolated from Salvia urmiensis. The structure was elucidated by a combination of 1D and 2D NMR, HRESIMS, and X-ray crystallographic analyses. The absolute con
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, there prodrugs and aza-analogues (Publications)
Fifty novel prodrugs and aza-analogues of 3,5-bis(4-amidinophenyl)isoxazole and its derivatives were prepared. Eighteen of the 24 aza-analogues exhibited IC50 values below 25nM against Trypanosoma bru
Mental health litaracy and the experience of depression in a community sample of gay men (Publications)
BACKGROUND: Gay men are at higher risk of suffering from a variety of psychiatric disorders, yet the mental health literacy of this population has remained largely unknown. METHODS: In 2007 and 2011,
Enantioselective synthesis of encecaline-derived potent antimalarial agents (Publications)
The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condens
Survey on animal bite injuries and their management to estimate human rabies deaths in N'Djamena, Chad (Publications)
OBJECTIVE: To estimate the annual human rabies incidence as a baseline prior to mass dog vaccination campaigns in N'Djaména, Chad. METHODS: Survey of animal bites, involving 50% of all healthcare prov
Activities of psilostachyin A and cynaropicrin against <em>Trypanosoma cruzi</em> in vitro and in vivo (Publications)
In vitro and in vivo activities against Trypanosoma cruzi were evaluated for two sesquiterpene lactones: psilostachyin A and cynaropicrin. Cynaropicrin had previously been shown to potently inhibit Af
