The fight against lymphatic filariasis: perceptions of community drug distributors during mass drug administration in coastal Kenya (Publications)
BACKGROUND: Lymphatic filariasis (LF), a neglected tropical disease (NTD) and leading cause of global disability, is endemic in 32 countries in Africa with almost 350 million people requiring regular
Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle (Publications)
Artemisin combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmodium. However, increased resistance to ACT highlights the importance o
TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like <em>Mycobacterium tuberculosis</em> (Publications)
TNF-alpha- as well as non-TNF-alpha-targeting biologics are prescribed to treat a variety of immune-mediated inflammatory disorders. The well-documented risk of tuberculosis progression associated wit
Use of insecticides in agriculture and the prevention of vector-borne diseases: population knowledge, attitudes, practices and beliefs in Elibou,... (Publications)
People's knowledge, attitudes, practices and beliefs (KAPB) pertaining to malaria are generally well described. However, little is known about population knowledge and awareness of insecticide resista
The immunology of other mycobacteria:<em> M. ulcerans, M. leprae</em> (Publications)
Mycobacterial pathogens can be categorized into three broad groups: Mycobacterium tuberculosis complex causing tuberculosis, M. leprae and M. lepromatosis causing leprosy, and atypical mycobacteria, o
Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in <em>Trypanosoma brucei</em> (Publications)
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated throug