Discovery and optimization of a compound series active against <em>Trypanosoma cruzi</em>, the causative agent of chagas disease (Publications)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronicall
Better data for better outcomes: the importance of process mapping and management in CRVS systems (Publications)
BACKGROUND: Despite attempts to apply standard methods proven to work in high-income nations, nearly all civil registration and vital statistics (CRVS) systems in low- and middle-income countries are
Prospective assessment of loss to follow-up: incidence and associated factors in a cohort of HIV-positive adults in rural Tanzania (Publications)
INTRODUCTION: Lifelong antiretroviral therapy (ART) improves health outcomes for HIV-positive individuals, but is jeopardized by irregular clinic attendance and hence poor adherence. Loss to follow-up
Where there is no hospital: improving the notification of community deaths (Publications)
BACKGROUND: Globally, an estimated two-thirds of all deaths occur in the community, the majority of which are not attended by a physician and remain unregistered. Identifying and registering these dea
ANACONDA: a new tool to improve mortality and cause of death data (Publications)
BACKGROUND: The need to monitor the Sustainable Development Goals (SDGs) and to have access to reliable and timely mortality data has created a strong demand in countries for tools that can assist the
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study (Publications)
Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among
Policy levers and priority-setting in universal health coverage: a qualitative analysis of healthcare financing agenda setting in Kenya (Publications)
BACKGROUND: Competing priorities in health systems necessitate difficult choices on which health actions and investments to fund: decisions that are complex, value-based, and highly political. In ligh
Extrapulmonary tuberculosis in HIV-infected patients in rural Tanzania: the prospective Kilombero and Ulanga antiretroviral cohort (Publications)
BACKGROUND: In sub-Saharan Africa, diagnosis and management of extrapulmonary tuberculosis (EPTB) in people living with HIV (PLHIV) remains a major challenge. This study aimed to characterize the epid
Epitope mapping and fine specificity of human T and B cell responses for novel candidate blood-stage malaria vaccine P27A (Publications)
P27A is a novel synthetic malaria vaccine candidate derived from the blood stage Plasmodium falciparum protein Trophozoite Exported Protein 1 (TEX1/PFF0165c). In phase 1a/1b clinical trials in malaria
