Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective and efficacious antitrypanosomal strategy (Publications)
The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality and economic hardship. Drug resistance and toxic side effects of
Association between advanced glycation end products and impaired fasting glucose: results from the SALIA study (Publications)
Advanced glycation end products (AGEs) may contribute to the development of type 2 diabetes and related complications, whereas their role in the early deterioration of glycaemia is unknown. While prev
The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions (Publications)
BACKGROUND: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to
AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa:... (Publications)
BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine,
Repurposing of anticancer drugs: <em>in vitro</em> and<em> in vivo</em> activities against <em>Schistosoma mansoni</em> (Publications)
BACKGROUND: Drug discovery for the neglected tropical disease schistosomiasis has a high priority. Anticancer drugs, especially protein kinase inhibitors, might serve as a starting point for drug disc
Maturation and mip-1beta production of cytomegalovirus-specific T cell responses in Tanzanian children, adolescents and adults: impact by HIV and... (Publications)
It is well accepted that aging and HIV infection are associated with quantitative and functional changes of CMV-specific T cell responses. We studied here the expression of Mip-1beta and the T cell ma