Dicationic biphenyl benzimidazole derivatives as antiprotozoal agents (Publications)
A series of biphenyl benzimidazoles diamidines 6a-i were synthesized from their respective diamidoximes, through the bis-O-acetoxyamidoxime followed by hydrogenation in glacial acetic acid/ethanol in
Dicationic DNA-targeted antiprotozoal agents: naphthalene replacement of benzimidazole (Publications)
A series of naphthalene analogues of highly active benzimidazole diamidines were synthesized using sequential Stille and Suzuki coupling reactions for preparation of the bis-nitrile intermediates. All
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles (Publications)
3,5-bis(4-amidinophenyl)isoxazole (3)-an analogue of 2,5-bis(4-amidinophenyl)furan (furamidine) in which the central furan ring is replaced by isoxazole-and 42 novel analogues were prepared by two gen
Azaterphenyl diamidines as antileishmanial agents (Publications)
Eighteen diamidino azaterphenyls and analogues were evaluated as anti-leishmanials; nine of the compounds gave IC50 values less than 1 microM, five exhibited values less than 0.40 microM, and two gave
Creating competent health-care specialists: the Swiss school of public health (Publications)
The Swiss health-care system (the second most expensive worldwide) is fragmented into 26 cantonal authorities for a population of 7.5 million. Cantons differ in policy, legislation and structure. Heal
