Activity and structure relationship of acridine derivatives against African trypanosomes (Publications)
48 newly synthesized acridine derivatives of different classes were screened for antitrypanosomal activity. They showed a dose dependent effect on Trypanosoma rhodesiense and T. brucei bloodstream for
Molecular analysis of carbohydrate-antibody interactions: case study using a <em>Bacillus anthracis</em> tetrasaccharide (Publications)
The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation
Airborne cultivable microflora and microbial transfer in farm buildings and rural dwellings (Publications)
Objectives Exposure to environments rich in microorganisms such as farms has been shown to protect against the development of childhood asthma and allergies. However, it remains unclear where, and how
Bis(oxyphenylene)benzimidazoles: a novel class of anti-<em>Plasmodium falciparum</em> agents (Publications)
A small library of 26 2,2'-[alkane-alpha,omega-diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhode
Antiparasitic agents: new drugs on the horizon (Publications)
The need for new drugs against tropical parasites such as Plasmodium falciparum and Trypanosoma brucei is persistent since problems with resistance and toxicity are jeopardizing the currently availabl
Reinfection with <em>Schistosoma haematobium</em> following school-based chemotherapy with praziquantel in four highly endemic villages in Côte... (Publications)
We present the comparative evaluation of school-based chemotherapy with praziquantel on Schistosoma haematobium reinfection patterns, 6, 12, 18 and 24 months after systematic treatment of schoolchildr
Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late stage central nervous system African... (Publications)
We report the discovery of novel boron-containing molecules, exemplified by N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl-2-trifluoromethylbenzam ide (AN3520) and 4-Fluoro-N-(1-hydroxy-1,3-dihydr