A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep (Publications)
Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs the quality of their sleep. Studies in mice revealed that the di
Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: <em>in vivo</em> studies (Publications)
Background: Chagas disease is caused by the parasite Trypanosoma cruzi, is endemic in Latin America and leads to an estimated 14,000 deaths per year and around 100 million people at risk of infection.
Air pollution and childhood leukaemia: a nationwide case-control study in Italy (Publications)
OBJECTIVES: Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leu
Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic... (Publications)
Large individual differences characterize the changes induced by sleep deprivation on neurobehavioral functions and rhythmic brain activity. To investigate adenosinergic mechanisms in these difference
Simple variables predict miserable outcome after intravenous thrombolysis (Publications)
BACKGROUND AND PURPOSE: To test the predictability of miserable outcome amongst ischaemic stroke patients receiving intravenous thrombolysis (IVT) based on a simple variables model (SVM) and to compar
<em>In vitro</em> metabolic profile and <em>in vivo</em> antischistosomal activity studies of (n6-praziquantel)Cr(Co)3 derivatives (Publications)
In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (?(6)-PZQ)Cr(CO)3 (1 and 2), by use of human live
DMSO-mediated ligand dissociation: renaissance for biological activity of <em>N</em>-heterocyclic-[Ru(n6-arene)CI2] drug candidates (Publications)
Slipped under the radar? 1 H NMR spectroscopic examination revealed that [Ru(?6 -arene)Cl2 (L)] (L=N-heterocyclic ligands) complexes readily undergo ligand exchange reaction in DMSO, a popular medium