Lipidomics identifies a requirement for peroxisomal function during influenza virus replication (Publications)
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking. Using a mass spectrometry-based lipidomic
<em>In vitro</em> and<em> In vivo</em> evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness (Publications)
African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a d
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization-recommended first-line drug for the treatment of severe malaria.
HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant <em>Carica papaya</em> L (Publications)
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf decoctions of Carica papaya have been traditionally used in some parts of Indonesia to treat and prevent malaria. Leaf extracts and fraction have been previously s
Vaccines safety; effect of supervision or SMS on reporting rates of adverse events following immunization (AEFI) with meningits vaccine... (Publications)
BACKGROUND: To ensure vaccines safety, given the weaknesses of the national pharmacovigilance system in Cameroon, there is a need to identify effective interventions that can contribute to improving A
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo (Publications)
Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of
Activity of praziquantel enantiomers and main metabolites against <em>Schistosoma mansoni</em> (Publications)
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice against schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only