The shape of the iceberg: quantification of submicroscopic <em>Plasmodium falciparum</em> and<em> Plasmodium vivax </em>parasitaemia and... (Publications)
BACKGROUND: The widespread presence of low-density asymptomatic infections with concurrent gametocytes may be a stumbling block for malaria elimination. This study investigated the asymptomatic reserv
Incidence and risk factors for hypertension among HIV patients in rural Tanzania - a prospective cohort study (Publications)
INTRODUCTION: Scarce data are available on the epidemiology of hypertension among HIV patients in rural sub-Saharan Africa. We explored the prevalence, incidence and risk factors for incident hyperten
A switch in regulatory T cells through farm-exposure during immune maturation in childhood (Publications)
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). T
Antimalarial pyrido[1,2-a]benzimidazoles: lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and <em>in... (Publications)
Further structure-activity relationship (SAR) studies on the recently identified pyrido[1,2-a]benzimidazole (PBI) antimalarials have led to the identification of potent, metabolically stable compounds
"You can save time if..."-a qualitative study on internal factors slowing down clinical trials in sub-Saharan Africa (Publications)
BACKGROUND: The costs, complexity, legal requirements and number of amendments associated with clinical trials are rising constantly, which negatively affects the efficient conduct of trials. In Sub-S
Monitoring of selected health indicators in children living in a copper mine development area in northwestern Zambia (Publications)
The epidemiology of malaria, anaemia and malnutrition in children is potentially altered in mining development areas. In a copper extraction project in northwestern Zambia, a health impact assessment
Low efficacy of albendazole against <em>Trichuris trichiura</em> infection in schoolchildren from Port Elizabeth, South Africa (Publications)
BACKGROUND: Albendazole is one of two standard drugs for the control of soil-transmitted helminthiasis. METHODS: A total of 149 schoolchildren from Port Elizabeth, South Africa, were examined for soil
Raising more domestic money for health: prospects for low- and middle-income countries (Publications)
Since the 2007/2008 financial crisis, the rhetoric in the development assistance dialogue has shifted away from raising more international funding for health, to requesting countries to move toward se
