Modelling heterogeneity in malaria transmission using large sparse spatio-temporal entomological data (Publications)
Background: Malaria transmission is measured using entomological inoculation rate (EIR), number of infective mosquito bites/person/unit time. Understanding heterogeneity of malaria transmission has be
Field comparison of circulating antibody assays <em>versus</em> circulating antigen assays for the detection of <em>Schistosomiasis japonica</em> in... (Publications)
BACKGROUND: Schistosomiasis remains a serious public health problem in affected countries, and routine, highly sensitive and cost-effective diagnostic methods are lacking. We evaluated two immunodiagn
Experimental infection of the pig with <em>Mycobacterium ulcerans</em>: a novel model for studying the pathogenesis of Buruli ulcer disease (Publications)
BACKGROUND: Buruli ulcer (BU) is a slowly progressing, necrotising disease of the skin caused by infection with Mycobacterium ulcerans. Non-ulcerative manifestations are nodules, plaques and oedema, w
<em>Plasmodium falciparum </em>infection and clinical indicators in relation to net coverage in central Côte d'Ivoire (Publications)
BACKGROUND: Sleeping under a net, particularly a long-lasting insecticidal net (LLIN), is associated with reduced malaria morbidity and mortality, but requires high coverage and adherence. In this stu
Essential evidence for guiding health system priorities and policies: anticipating epidemiological transition in Africa (Publications)
Background: Despite indications that infection-related mortality in sub-Saharan Africa may be decreasing and the burden of non-communicable diseases increasing, the overwhelming reality is that health
Emergence of a new epidemic <em>Neisseria meningitidis</em> serogroup A clone in the African meningitis belt: high-resolution picture of genomic... (Publications)
In the African "meningitis belt," outbreaks of meningococcal meningitis occur in cycles, representing a model for the role of host-pathogen interactions in epidemic processes. The periodicity of the e
Estimating population and livestock density of mobile pastoralists and sedentary settlements in the south-eastern Lake Chad area (Publications)
Mobile pastoralists provide major contributions to the gross domestic product in Chad, but little information is available regarding their demography. The Lake Chad area population is increasing, resu
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion (Publications)
LJ001 is a lipophilic thiazolidine derivative that inhibits the entry of numerous enveloped viruses at non-cytotoxic concentrations (IC50?0.5 µM), and was posited to exploit the physiological differen