Pseudilins: halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD (Publications)
The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis have been identified as attractive targets with novel modes of action for the development of herbicides for crop protection and ag
Electrophysiological markers and predictors of the disease course in primary progressive multiple sclerosis (Publications)
BACKGROUND: Currently no valid surrogate marker exists for primary progressive multiple sclerosis (PPMS). OBJECTIVE: Our aim was to prospectively investigate multimodal evoked potentials (EPs) as mark
Luftverschmutzung und Gesundheit - Optionen in der klinischen Beratung (Publications)
While air quality is usually an environmental condition patients can little do about, there are a few options and decisions that modify the personal exposure and risk. Location - in particular the res
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH kinase (PI(4)K), as
Prediction of MS disability by multimodal evoked potentials: investigation during relapse or in the relapse-free interval? (Publications)
OBJECTIVE: Little is known about optimal timing of multimodal evoked potential (EP)-investigations regarding prediction of MS disability. The aim of this study was to investigate whether timing of EP-
B-type natriuretic peptide in patients undergoing orthopaedic surgery: a prospective cohort study (Publications)
BACKGROUND AND OBJECTIVE: Postoperative cardiac complications pose a substantial risk to patients undergoing orthopaedic surgery. METHODS: B-type natriuretic peptide (BNP) was determined preoperativel
The spatial distribution of <em>Schistosoma mansoni</em> infection in four regions of western Côte d'Ivoire (Publications)
Schistosomiasis poses a considerable public health burden in sub- Saharan Africa and a sound understanding of the spatial distribution facilitates to better target control interventions. The objective
PLS-prediction and confirmation of hydrojuglone glucoside as the antitrypanosomal constituent of <em>Juglans</em> spp. (Publications)
Naphthoquinones (NQs) occur naturally in a large variety of plants. Several NQs are highly active against protozoans, amongst them the causative pathogens of neglected tropical diseases such as human