Clinical markers of asthma and IgE assessed in parents before conception predicts asthma and hay fever in the offspring (Publications)
BACKGROUND: Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's
Time to harmonize national ambient air quality standards (Publications)
OBJECTIVES: The World Health Organization has developed ambient air quality guidelines at levels considered to be safe or of acceptable risk for human health. These guidelines are meant to support gov
Unmasking inequalities: sub-national maternal and child mortality data from two urban slums in Lagos, Nigeria tells the story (Publications)
INTRODUCTION: Nigeria has one of the highest maternal mortality ratios in the world as well as high perinatal mortality. Unfortunately, the country does not have the resources to assess this critical
Structure and biosynthesis of isatropolones, bioactive amine-scavenging fluorescent natural products from <em>streptomyces Go66</em> (Publications)
The natural products isatropolone A-C (1-3) were reisolated from Streptomyces Go66, with 1 and 3 showing potent activity against Leishmania donovani. They contain a rare tropolone ring derived from a
Geostatistical modelling of malaria indicator survey data to assess the effects of interventions on the geographical distribution of malaria... (Publications)
BACKGROUND: Malaria burden in Uganda has declined disproportionately among regions despite overall high intervention coverage across all regions. The Uganda Malaria Indicator Survey (MIS) 2014-15 was
Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)
Introduction of water-solubilizing groups on the 5-phenyl ring of a 2-aminopyrazine series led to the identification of highly potent compounds against the blood life-cycle stage of the human malaria
Gametocyte carriage in uncomplicated <em>Plasmodium falciparum</em> malaria following treatment with artemisinin combination therapy: a systematic... (Publications)
BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, paras