Mental distress and health-related quality of life in <em>gambiense </em>human African trypanosomiasis: a case-control study in the Democratic... (Publications)
BACKGROUND: The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known. METHODS:
Competent and deficient provision of childbirth services: a descriptive observational study assessing the quality of intrapartum care in two provinces... (Publications)
BACKGROUND: A majority of women in the Democratic Republic of the Congo (DRC) give birth in a health facility, but maternal and newborn mortality remains high. In rural areas, the quality of facility-
Infection intensity-dependent accuracy of reagent strip for the diagnosis of <em>Schistosoma haematobium </em>and estimation of treatment prevalence... (Publications)
BACKGROUND: Reagent strip to detect microhematuria as a proxy for Schistosoma haematobium infections has been considered an alternative to urine filtration for individual diagnosis and community-based
Population pharmacokinetics of antimalarial naphthoquine in combination with artemisinin in Tanzanian children and adults: dose optimization (Publications)
The combination antimalarial therapy of artemisinin-naphthoquine (ART-NQ) was developed as a single-dose therapy, aiming to improve adherence relative to the multiday schedules of other artemisinin co
Presenting a comprehensive multi-scale evaluation framework for participatory modelling programs: a scoping review (Publications)
INTRODUCTION: Systems modelling and simulation can improve understanding of complex systems to support decision making, better managing system challenges. Advances in technology have facilitated acces
Vaccine hesitancy and HPV vaccine uptake among male and female youth in Switzerland: a cross-sectional study (Publications)
OBJECTIVES: Identifying factors associated with human papillomavirus (HPV) vaccine uptake is essential for designing successful vaccination programmes. We aimed to examine the association between vacc
Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12) (Publications)
The catechol derivative RC-12 (WR 27653) (1) is one of the few non-8-aminoquinolines with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) mod
Use of index testing to close the gap in HIV diagnosis among older people in Rwanda: analysis of data from a public health programme (Publications)
BACKGROUND: As Rwanda inches closer to the UNAIDS HIV first 95 of knowing one's HIV status by 2030, finding the remaining HIV-positive individuals could be difficult by use of passive methods. Index t
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183 (Publications)
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibi
Gut microbiota targeted approach in the management of chronic liver diseases (Publications)
The liver is directly connected to the intestines through the portal vein, which enables the gut microbiota and gut-derived products to influence liver health. There is accumulating evidence of decrea
