Long-term exposure to ambient air pollution and asthma symptom score in the CONSTANCES cohort (Publications)
BACKGROUND: The asthma symptom score allows to consider asthma as a continuum and to investigate its risk factors. One previous study has investigated the association between asthma score and air poll
G-quadruplexes in helminth parasites (Publications)
Parasitic helminths infecting humans are highly prevalent infecting approximately 2 billion people worldwide, causing inflammatory responses, malnutrition and anemia that are the primary cause of morb
Our exciting journey to ACT-451840 (Publications)
We describe our work resulting in the selection of ACT-451840 ( 38 ) as a novel antimalarial drug with a novel mode of action. The compound was broadly characterized in vitro as well as in vivo in rat
37 years of forest monitoring in Switzerland: drought effects on<em> Fagus sylvatica</em> (Publications)
European beech is one of the most important deciduous tree species in natural forest ecosystems in Central Europe. Its dominance is now being questioned by the emerging drought damages due to the incr
Changes in household wealth in communities living in proximity to a large-scale copper mine in Zambia (Publications)
Large-scale mining can alter the living conditions of surrounding communities in positive and negative ways. A health impact assessment conducted in the context of a newly developed large-scale copper
Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S (Publications)
Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review ill
The potential impact of human visceral leishmaniasis vaccines on population incidence (Publications)
Human visceral leishmaniasis (VL) vaccines are currently under development and there is a need to understand their potential impact on population wide VL incidence. We implement four characteristics f
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone (Publications)
BACKGROUND: Treatment of schistosomiasis, a neglected disease, relies on just one partially effective drug, praziquantel. We revisited the 9-acridanone hydrazone, Ro 15-5458, a largely forgotten antis
Characteristics of persistent hotspots of <em>Schistosoma mansoni</em> in western Côte d'Ivoire (Publications)
BACKGROUND: Preventive chemotherapy with praziquantel is the cornerstone of schistosomiasis control. However, in some social-ecological settings, the prevalence and/or intensity of Schistosoma infecti